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Titolo:
Effects of acute hypobaric hypoxia on regional cerebral blood flow distribution: a Single Photon Emission Computed Tomography study in humans
Autore:
Pagani, M; Ansjon, R; Lind, F; Uusijarvi, J; Sumen, G; Jonsson, C; Salmaso, D; Jacobsson, H; Larsson, SA;
Indirizzi:
Karolinska Hosp, Nucl Med Sect, SE-17176 Stockholm, Sweden Karolinska Hosp Stockholm Sweden SE-17176 ct, SE-17176 Stockholm, Sweden CNR, Inst Expt Med, Rome, Italy CNR Rome ItalyCNR, Inst Expt Med, Rome, Italy Karolinska Hosp, Dept Anaesthesiol, S-10401 Stockholm, Sweden Karolinska Hosp Stockholm Sweden S-10401 siol, S-10401 Stockholm, Sweden Stockholm Univ, Dept Med Radiat Phys, S-10691 Stockholm, Sweden Stockholm Univ Stockholm Sweden S-10691 Phys, S-10691 Stockholm, Sweden CNR, Inst Psychol, Rome, Italy CNR Rome ItalyCNR, Inst Psychol, Rome, Italy Karolinska Hosp, Dept Diagnost Radiol, S-10401 Stockholm, Sweden Karolinska Hosp Stockholm Sweden S-10401 diol, S-10401 Stockholm, Sweden
Titolo Testata:
ACTA PHYSIOLOGICA SCANDINAVICA
fascicolo: 3, volume: 168, anno: 2000,
pagine: 377 - 383
SICI:
0001-6772(200003)168:3<377:EOAHHO>2.0.ZU;2-G
Fonte:
ISI
Lingua:
ENG
Soggetto:
MOUNT EVEREST; ALTITUDE; INJURY; RATS; PERFORMANCE; MECHANISMS; EXPOSURE; DEFICITS; SYSTEM; OXYGEN;
Keywords:
basal ganglia; hypobaric hypoxia; motor cortex; regional cerebral blood flow; Single Photon Emission Computed Tomography;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
31
Recensione:
Indirizzi per estratti:
Indirizzo: Pagani, M Karolinska Hosp, Nucl Med Sect, SE-17176 Stockholm, Sweden Karolinska Hosp Stockholm Sweden SE-17176 76 Stockholm, Sweden
Citazione:
M. Pagani et al., "Effects of acute hypobaric hypoxia on regional cerebral blood flow distribution: a Single Photon Emission Computed Tomography study in humans", ACT PHYSL S, 168(3), 2000, pp. 377-383

Abstract

Single Photon Emission Computed Tomography (SPECT) and radiopharmaceuticalstabilizing agents allowed us to investigate regional cerebral blood flow (CBF) distribution in six resting healthy subjects during acute laboratory hypobaric hypoxic conditions, in the hypobaric experiment stabilized (TC)-T-99m-D,L-hexamethyl-propylene amine oxime was injected 40 min after reaching hypoxic conditions corresponding to an altitude of 5500 m above sea level. Arterial blood sample was taken after five additional minutes; Mean arterial oxygen pressure and haemoglobin saturation were 28 mmHg and 56%, respectjvely. The control experiment was performed similarly, apart from barometric pressure and blood gas analysis. We analysed CBF distribution in 12 regions of functional interest bilaterally in frontal, parietal, temporal, occipital cortex, in the hippocampus, in the basal ganglia and other central structures of brain. No overall effect of hypoxia on normalized regional CBF distribution in the considered regions was found. Motor cortex (Brodmann 4)and basal ganglia were the only regions in which hypobaric hypoxia significantly increased relative distribution of the radiopharmaceutical [F(1,5) =18.30; P < 0.008 and F(1,5) = 10.85; P < 0.022, respectively]. Despite severe hypoxia, we did not observe any major regional CBF redistribution. We found ci small-relative increase in blood flow to the motor cortex and the basal ganglia, at rest after 40 min: of hypobaric hypoxia, suggesting a preferential compensatory mechanism of these functional regions of brain.

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Documento generato il 05/04/20 alle ore 03:20:36