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Titolo:
Prognostic significance of serous and clear cell adenocarcinoma in surgically staged endometrial carcinoma
Autore:
Sakuragi, N; Hareyama, H; Todo, Y; Yamada, H; Yamamoto, R; Fujino, T; Sagawa, T; Fujmoto, S;
Indirizzi:
Hokkaido Univ, Sch Med, Dept Obstet & Gynecol, Sapporo, Hokkaido 0608638, Japan Hokkaido Univ Sapporo Hokkaido Japan 0608638 oro, Hokkaido 0608638, Japan
Titolo Testata:
ACTA OBSTETRICIA ET GYNECOLOGICA SCANDINAVICA
fascicolo: 4, volume: 79, anno: 2000,
pagine: 311 - 316
SICI:
0001-6349(200004)79:4<311:PSOSAC>2.0.ZU;2-Z
Fonte:
ISI
Lingua:
ENG
Soggetto:
PAPILLARY ADENOCARCINOMA; P53; RECURRENCE; EXPRESSION; PATTERNS; SUBTYPES;
Keywords:
clear cell adenocarcinoma; endometrial carcinoma; lymph node metastasis; serous adenocarcinoma; survival;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
29
Recensione:
Indirizzi per estratti:
Indirizzo: Sakuragi, N Hokkaido Univ, Sch Med, Dept Obstet & Gynecol, Sapporo, Hokkaido 0608638, Japan Hokkaido Univ Sapporo Hokkaido Japan 0608638 o 0608638, Japan
Citazione:
N. Sakuragi et al., "Prognostic significance of serous and clear cell adenocarcinoma in surgically staged endometrial carcinoma", ACT OBST SC, 79(4), 2000, pp. 311-316

Abstract

Background The serous adenocarcinoma (SA) and clear cell adenocarcinoma (CCA) of endometrium have been shown to be associated with high relapse rate and poor survival. It is not clear whether prognostic significance of thesespecific cell types of tumor is independent of retroperitoneal lymph node metastasis and other histopathologic prognostic factors in endometrial carcinoma. Methods. We examined 240 consecutive patients with clinical stage I to stage III endometrial carcinoma who were treated prospectively with radical surgery and/or platinum-based chemotherapy. Surgery included extended hysterectomy, bilateral salpingo-oophorectomy, and systematic pelvic and paraaortic lymph node dissection. Prognostic significance of various histopathologicfactors was determined by Cox regression analysis. Results. SA/CCA were more frequently associated with deep myometrial invasion, high nuclear grade (G3), lymph-vascular space invasion (LVSI), and pelvic lymph node metastasis when compared to endometrioid adenocarcinoma (EMA). Of 216 clinically staged stage I or II disease, seven of 12 cases of SA/CCA had extrauterine disease. This incidence was much higher than that for EMA (46/204) (p<0.01). A multivariate Cox regression analysis revealed thatcell type, grade, LVSI, and paraaortic node metastasis (PANM) were independent prognosticators. Conclusions. Prognosis of patients with endometrial carcinoma depends on cell type, grade, LVSI, and PANM. Poor prognosis for patients with SA/CCA isindependent of lymph node metastasis and other histopathologic prognostic factors. The SA/CCA should be strictly discriminated from EMA.

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Documento generato il 25/11/20 alle ore 00:52:08