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Titolo:
Obsessive-compulsive disorder, frontostriatal system and effect upon the serotonergic system
Autore:
Baving, L; Schmidt, MH;
Indirizzi:
Zent Inst Seel Gesundheit, Klin Psychiat & Psychotherapie Kindes & Jugendalt, D-68072 Mannheim, Germany Zent Inst Seel Gesundheit Mannheim Germany D-68072 072 Mannheim, Germany
Titolo Testata:
ZEITSCHRIFT FUR KINDER-UND JUGENDPSYCHIATRIE UND PSYCHOTHERAPIE
fascicolo: 1, volume: 28, anno: 2000,
pagine: 35 - 44
SICI:
1422-4917(200002)28:1<35:ODFSAE>2.0.ZU;2-Q
Fonte:
ISI
Lingua:
GER
Soggetto:
CEREBRAL BLOOD-FLOW; GLUCOSE METABOLIC RATES; DOUBLE-BLIND; CLOMIPRAMINE TREATMENT; EMISSION TOMOGRAPHY; COMPUTED-TOMOGRAPHY; BEHAVIOR-THERAPY; D-FENFLURAMINE; CHILDREN; ADOLESCENTS;
Keywords:
obsessive-compulsive disorder; frontal brain; basal ganglia; neuroimaging; serotonin reuptake inhibitors; sulpiride;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Social & Behavioral Sciences
Citazioni:
62
Recensione:
Indirizzi per estratti:
Indirizzo: Baving, L Zent Inst Seel Gesundheit, Klin Psychiat & Psychotherapie Kindes& Jugendalt, Postfach 12 21 20, D-68072 Mannheim, Germany Zent Inst Seel Gesundheit Postfach 12 21 20 Mannheim Germany D-68072
Citazione:
L. Baving e M.H. Schmidt, "Obsessive-compulsive disorder, frontostriatal system and effect upon the serotonergic system", Z KIND JUG, 28(1), 2000, pp. 35-44

Abstract

Objectives: Focal issues of recent research on obsessive-compulsive disorders have been the involvement of the frontostriatal system in the patho-physiology, as well as the manner of effect and efficacy of the serotonin re-uptake inhibitors the unfold their specific efficacy in the frontostriatal system. The course of treatment among adolescent inpatients with obsessive-compulsive disorder was analyzed with regard to the medications used and their effects upon the course of treatment. Methods: The data for all adolescents with obsessive-compulsive disorder admitted as inpatients to the Hospital for Child and Adolescent Psychiatry in Mannheim since 01.01.1990 were analyzed with regard to medication and theparameters for course and outcome. Results: Five patients dropped out of treatment, five patients received nomedication, eight received sulpiride, ten were treated with clomipramine, and three with fluvoxamine. The average length of inpatient stay was longerfor the groups treated with sulpiride and clomipramine than for the group that received no medication, but equivalent for theses two groups. The success of treatment for obsessive-compulsive disorder was rated as higher in these two groups than in the group without medication. On sulpiride, patients gained weight and exhibited fatigue and increased levels of prolactin. Onclomipramine, half of the patients exhibited cardiac side effects. Conclusions: This small, nonrandomized medicated sample analyzed under non-double-blind conditions shows no difference in the efficacy of clomipramine and sulpiride under post hoc analysis. Rather, the side effects that occurred in patients on clomipramine indicate a more frequent use of SSRI to increase compliance as regards medication intake.

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Documento generato il 06/04/20 alle ore 05:02:55