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Titolo:
Human immunosenescence: the prevailing of innate immunity, the failing of clonotypic immunity, and the filling of immunological space
Autore:
Franceschi, C; Bonafe, M; Valensin, S;
Indirizzi:
Italian Natl Res Ctr Aging, Dept Gerontol Res, Ancona, Italy Italian Natl Res Ctr Aging Ancona Italy ept Gerontol Res, Ancona, Italy Univ Bologna, Dept Expt Pathol, I-40126 Bologna, Italy Univ Bologna Bologna Italy I-40126 t Expt Pathol, I-40126 Bologna, Italy
Titolo Testata:
VACCINE
fascicolo: 16, volume: 18, anno: 2000,
pagine: 1717 - 1720
SICI:
0264-410X(20000225)18:16<1717:HITPOI>2.0.ZU;2-Z
Fonte:
ISI
Lingua:
ENG
Soggetto:
T-CELLS; CENTENARIANS; CANCER; CD4(+); PEOPLE;
Keywords:
immunosenescence; innate immunity; stress; centenarians; immunological memory;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Agriculture,Biology & Environmental Sciences
Life Sciences
Citazioni:
20
Recensione:
Indirizzi per estratti:
Indirizzo: Franceschi, C Italian Natl Res Ctr Aging, Dept Gerontol Res, Ancona, ItalyItalian Natl Res Ctr Aging Ancona Italy es, Ancona, Italy
Citazione:
C. Franceschi et al., "Human immunosenescence: the prevailing of innate immunity, the failing of clonotypic immunity, and the filling of immunological space", VACCINE, 18(16), 2000, pp. 1717-1720

Abstract

According to the remodeling theory of aging we proposed several years ago,the current data on human immunosenescence depicts a complex scenario where clonotypical immunity deteriorates, while ancestral innate/natural immunity is largely conserved or even up-regulated with age. Under an evolutionary perspective, antigens are the cause of a persistent life-long antigenic stress, responsible for the accumulation of effector CD8+/CD28- T cells, thedecrease of naive T cells (CD95-) and the marked shrinkage of T cell repertoire with age. Concomitantly, NK cytotoxicity, chemotaxis, phagocytosis and complement activities remain unaffected or negligibly affected, in comparison to clonotypical immunity. Thus, immunosenescence is not a random deteriorative phenomenon but appears to inversely recapitulate an evolutionary pattern. On the whole, immunosenescence can be envisaged as the result of the continuous challenge of the unavoidable exposure to a variety of potential antigens (viruses, bacteria, but also food and self molecules among others). From this perspective antigens are nothing else than a particular type of stressor and immunosenescence appears to be the price paid to immunological memory, i.e. one of the main characteristics of the most evolutionary recent and sophisticated type of immunity. Together with the age-related thymic involution, and the consequent age-related decrease of thymic output ofnew T cells, this situation leaves the body practically devoid of virgin Tcells, and thus likely more prone to a variety of infectious and non infectious diseases. (C) 2000 Elsevier Science Ltd. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 20/09/20 alle ore 00:49:37