Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
ANTICONVULSAN ACTION OF -DIHYDROXY-6-NITRO-7-SULFAMOYL-BENZO(F)QUINOXALINE IN IMMATURE WATS - COMPARISON WITH THE EFFECTS ON MOTOR-PERFORMANCE
Autore:
MARES P; MIKULECKA A; POMETLOVA M;
Indirizzi:
ACAD SCI CZECH REPUBL,INST PHYSIOL,VIDENSKA 1083 CZ-14220 PRAGUE 4 CZECH REPUBLIC CHARLES UNIV,DEPT PATHOPHYSIOL,MED SCH 3 PRAGUE CZECH REPUBLIC
Titolo Testata:
The Journal of pharmacology and experimental therapeutics
fascicolo: 3, volume: 281, anno: 1997,
pagine: 1120 - 1126
SICI:
0022-3565(1997)281:3<1120:AAO->2.0.ZU;2-9
Fonte:
ISI
Lingua:
ENG
Soggetto:
AMINO-ACID RECEPTORS; NON-NMDA ANTAGONISTS; METHYL-D-ASPARTATE; GLUTAMATE ANTAGONISTS; POSTNATAL-DEVELOPMENT; INDUCED SEIZURES; RAT FOREBRAIN; NBQX; GYKI-52466; ONTOGENY;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
42
Recensione:
Indirizzi per estratti:
Citazione:
P. Mares et al., "ANTICONVULSAN ACTION OF -DIHYDROXY-6-NITRO-7-SULFAMOYL-BENZO(F)QUINOXALINE IN IMMATURE WATS - COMPARISON WITH THE EFFECTS ON MOTOR-PERFORMANCE", The Journal of pharmacology and experimental therapeutics, 281(3), 1997, pp. 1120-1126

Abstract

Anticonvulsant action oi -dihydroxy-6-nitro-7-sulfamoyl-benzo(f)quinoxaline (NBQX), a competitive antagonist at non-N-methyl-o-aspartate receptors for excitatory amino acids, was studied in a model of corticalepileptic afterdischarges (ADs) in 12-, 18- and 25-day-old rat pups with implanted electrodes. Electrical stimulation of sensorimotor cortex was repeated four times with 20-min intervals, NBQX (in doses of 10,30, 60 or 90 mg/kg i.p.) or solvent (dimethyl sulfoxide, 1 ml/kg i.p.) were injected 10 min after the first afterdischarge. Dimethyl sulfoxide did not change the phenomena recorded; NBQX shortened ADs or at least blocked progressive prolongation observed under control conditions. Intensity of movements accompanying stimulation decreased after NBQX, and clonic movements accompanying ADs were suppressed in a dose-dependent manner. The highest dose of NBQX disabled the animals; therefore, the action of this drug on motor skills was studied in another groupof animals. Even the dose of 30 mg/kg NBQX interfered with motor performance in 12- and 18-day-old rat pups, 25-day-old rat pups were more resistant to this action. NBQX exhibited only moderate antiepileptic action (suppression of progressive lengthening of ADs) at doses where unwanted side effects were absent.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/04/20 alle ore 06:36:57