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Titolo:
Rapid change of platelet aggregability in acute hyperglycemia - Detection by a novel laser-light scattering method
Autore:
Sakamoto, T; Ogawa, H; Kawano, H; Hirai, N; Miyamoto, S; Takazoe, K; Soejima, H; Kugiyama, K; Yoshimura, M; Yasue, H;
Indirizzi:
Kumamoto Univ, Sch Med, Dept Cardiovasc Med, Kumamoto 8608556, Japan Kumamoto Univ Kumamoto Japan 8608556 iovasc Med, Kumamoto 8608556, Japan
Titolo Testata:
THROMBOSIS AND HAEMOSTASIS
fascicolo: 3, volume: 83, anno: 2000,
pagine: 475 - 479
SICI:
0340-6245(200003)83:3<475:RCOPAI>2.0.ZU;2-E
Fonte:
ISI
Lingua:
ENG
Soggetto:
ACUTE MYOCARDIAL-INFARCTION; ACTIVATOR INHIBITOR ACTIVITY; CORONARY-ARTERY; NITRIC-OXIDE; L-ARGININE; AGGREGATION; COMPLICATIONS; ANGINA;
Keywords:
platelet aggregability; hyperglycemia; glucose tolerance test;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
26
Recensione:
Indirizzi per estratti:
Indirizzo: Ogawa, H Kumamoto Univ, Sch Med, Dept Cardiovasc Med, 1-1-1 Honjo, Kumamoto 8608556, Japan Kumamoto Univ 1-1-1 Honjo Kumamoto Japan 8608556 8608556, Japan
Citazione:
T. Sakamoto et al., "Rapid change of platelet aggregability in acute hyperglycemia - Detection by a novel laser-light scattering method", THROMB HAEM, 83(3), 2000, pp. 475-479

Abstract

We examined the alteration of platelet aggregability in acute hyperglycemia during 75-gram oral glucose tolerance tests (OGTT). Twenty subjects underwent 75-gram OGTT and venous blood samples were obtained before (0 min), 60, 120 and 180 min postload. Platelet aggregability shown as the number of small platelet aggregates was measured with a novel laser-light scattering (LS) method. Platelet aggregability increased in parallel with both glucose and immunoreactive insulin (IRI) levels. The number of mean small aggregates at 60 min (12.30 +/- 1.10 X 10(4)) was significantly higher than the one at 0 min (8.32 +/- 0.88 X 10(4), p <0.001), 120 min (10.63 +/- 0.98 X 10(4), p <0.05) and 180 min (8.28 +/- 0.84 x 10(4), p <0.001) (mean +/- SEM). Small aggregates correlated positively with plasma glucose levels at 60 min postload (r = 0.67, p = 0.001) while not with IRI. It might be important to suppress transient hyperglycemia for preventing the onset of acute coronarysyndromes that could be closely related to platelet hyperaggregability.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 26/11/20 alle ore 07:53:59