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Titolo:
Mucinous cystic neoplasms of the pancreas
Autore:
Wilentz, RE; Albores-Saavedra, J; Hruban, RH;
Indirizzi:
Johns Hopkins Med Inst, Dept Pathol, Baltimore, MD 21205 USA Johns HopkinsMed Inst Baltimore MD USA 21205 ol, Baltimore, MD 21205 USA Johns Hopkins Med Inst, Dept Oncol, Baltimore, MD 21205 USA Johns Hopkins Med Inst Baltimore MD USA 21205 ol, Baltimore, MD 21205 USA Univ Texas, SW Med Ctr, Dept Pathol, Dallas, TX USA Univ Texas Dallas TX USA Texas, SW Med Ctr, Dept Pathol, Dallas, TX USA
Titolo Testata:
SEMINARS IN DIAGNOSTIC PATHOLOGY
fascicolo: 1, volume: 17, anno: 2000,
pagine: 31 - 42
SICI:
0740-2570(200002)17:1<31:MCNOTP>2.0.ZU;2-G
Fonte:
ISI
Lingua:
ENG
Soggetto:
RAS ONCOGENE MUTATIONS; ACINAR CELL TUMOR; K-RAS; CLINICOPATHOLOGICAL ENTITY; MICROCYSTIC-ADENOMAS; HYPERSECRETING TUMOR; ELECTRON-MICROSCOPY; PAPILLARY NEOPLASM; LATENT MALIGNANCY; CYSTADENOMA;
Keywords:
mucinous cystic neoplasm; mucinous cystadenocarcinoma; mucinous cystadenoma; pancreas; adenocarcinoma; prognosis; pancreatic neoplasms; cystic neoplasms;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
68
Recensione:
Indirizzi per estratti:
Indirizzo: Hruban, RH Johns Hopkins Hosp, Dept Pathol, Meyer 7-181,600 N Wolfe St, Baltimore, MD21287 USA Johns Hopkins Hosp Meyer 7-181,600 N Wolfe St Baltimore MD USA 21287
Citazione:
R.E. Wilentz et al., "Mucinous cystic neoplasms of the pancreas", SEM DIAGN P, 17(1), 2000, pp. 31-42

Abstract

Since their initial description, mucinous cystic neoplasms have been difficult to classify. This article attempts to clarify histological, clinical, and genetic criteria so that the pathologist can categorize each mucinous cystic neoplasm into 1 of 4 possible categories, Mucinous cystadenomas contain a single layer of mucin-producing, columnar epithelium lacking significant atypia. Borderline mucinous cystic neoplasms contain cells with moderateatypia, Mucinous cystic neoplasms with in situ carcinoma show significant architectural and cytological atypia. When invasive carcinoma is present inassociation with a mucinous cystic neoplasm, then the diagnosis of invasive mucinous cystadenocarcinoma should be made, The categorization of mucinous cystic neoplasms into these groups is essential because it accurately predicts outcome, provided that the tumor has been sampled and examined thoroughly. Completely removed mucinous cystadenomas, borderline mucinous cystic neoplasms, and mucinous cystic neoplasms with in situ carcinoma follow benign courses, Partial resection should be avoided as evidence suggests that mucinous cystic neoplasms can progress from adenomas to borderline lesions to carcinomas in situ to invasive carcinomas over time; partial resection should be avoided if possible, Modern molecular genetic techniques are helping to unravel the origins of rare variants of mucinous cystic tumors, such as the mucinous cystic tumor with an associated osteoclast-like giant cell tumor and the mucinous cystic tumor with sarcomatous stroma. Copyright (C) 2000 by W.B. Saunders Company.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 28/11/20 alle ore 04:43:15