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Titolo:
Mild hyperthermia-induced apoptosis is dependent on p53 in human lymphoid cells
Autore:
Seo, YR; Smith, ML; Han, SS; Fairbairn, DW; ONeill, KL; Ryu, JC;
Indirizzi:
Korea Adv Inst Sci & Technol, Toxicol Lab, Seoul 130650, South Korea KoreaAdv Inst Sci & Technol Seoul South Korea 130650 30650, South Korea Indiana Univ, Sch Med, Ctr Canc, Indianapolis, IN 46202 USA Indiana Univ Indianapolis IN USA 46202 r Canc, Indianapolis, IN 46202 USA Korea Univ, Grad Sch Biotechnol, Cell Biol Lab, Seoul 136701, South Korea Korea Univ Seoul South Korea 136701 Biol Lab, Seoul 136701, South Korea Brigham Young Univ, Dept Microbiol, Provo, UT 84602 USA Brigham Young Univ Provo UT USA 84602 Dept Microbiol, Provo, UT 84602 USA
Titolo Testata:
RESEARCH COMMUNICATIONS IN MOLECULAR PATHOLOGY AND PHARMACOLOGY
fascicolo: 3, volume: 104, anno: 1999,
pagine: 285 - 292
SICI:
1078-0297(1999)104:3<285:MHAIDO>2.0.ZU;2-N
Fonte:
ISI
Lingua:
ENG
Soggetto:
HEAT-SHOCK; FIBROBLASTS; REPAIR; UV;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
16
Recensione:
Indirizzi per estratti:
Indirizzo: Ryu, JC Korea Adv Inst Sci & Technol, Toxicol Lab, POB 131, Seoul 130650, South Korea Korea Adv Inst Sci & Technol POB 131 Seoul South Korea 130650 rea
Citazione:
Y.R. Seo et al., "Mild hyperthermia-induced apoptosis is dependent on p53 in human lymphoid cells", RES COM M P, 104(3), 1999, pp. 285-292

Abstract

Mild hyperthermia is known to enhance apoptosis. The p53 tumor-suppressor gene product has been shown to function in apoptosis in response to genotoxic stress. However, there is little information regarding the mechanism of p53-dependent apoptosis induced by heat stress. In present study, a p53 contribution in mild hyperthermia-induced apoptosis was investigated in human lymphoid system. After 30-minute exposure at 44 degrees C, the accumulationof p53 protein was clearly observed in TK6 and ML-1 cells. Using comet assay, the more significant sensitivity to hyperthermic apoptosis was found inTK6 (wild-type p53) than in WI-L2-NS (mutated in p53). Furthermore, the significantly rapid shifting from early apoptotic phase to late apoptotic wasobserved in heat-induced p53 TK6 cells. These findings suggest that p53-dependent apoptosis is efficaciously induced by mild hyperthermia as non-genotoxic stress in human lymphoid system.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 28/09/20 alle ore 12:11:07