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Titolo:
SPECIES-DIFFERENCES IN THE ROLE OF EXCITATORY AMINO-ACIDS IN EXPERIMENTAL PARKINSONISM
Autore:
FORNAI F; VAGLINI F; MAGGIO R; BONUCCELLI U; CORSINI GU;
Indirizzi:
UNIV PISA,INST PHARMACOL,VIA ROMA 55 I-56100 PISA ITALY UNIV PISA,INST CLIN NEUROL I-56100 PISA ITALY ASSOC ANNI VERDI I-00152 ROME ITALY
Titolo Testata:
Neuroscience and biobehavioral reviews
fascicolo: 4, volume: 21, anno: 1997,
pagine: 401 - 415
SICI:
0149-7634(1997)21:4<401:SITROE>2.0.ZU;2-T
Fonte:
ISI
Lingua:
ENG
Soggetto:
D-ASPARTATE RECEPTORS; DOPAMINERGIC NEUROTOXIN 1-METHYL-4-PHENYL-1,2,3,6-TETRAHYDROPYRIDINE; 1-METHYL-4-PHENYLPYRIDINIUM ION MPP+; CENTRAL CATECHOLAMINE NEURONS; MPTP-INDUCED PARKINSONISM; STRIATAL DOPAMINE; SUBSTANTIA-NIGRA; RAT STRIATUM; NMDA-RECEPTOR; MOUSE-BRAIN;
Keywords:
MPTP; METHAMPHETAMINE; DOPAMINE; EXPERIMENTAL PARKINSONISM; EXCITATORY AMINO ACID; NIGROSTRIATAL PATHWAY; NMDA-ANTAGONISTS;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
156
Recensione:
Indirizzi per estratti:
Citazione:
F. Fornai et al., "SPECIES-DIFFERENCES IN THE ROLE OF EXCITATORY AMINO-ACIDS IN EXPERIMENTAL PARKINSONISM", Neuroscience and biobehavioral reviews, 21(4), 1997, pp. 401-415

Abstract

The present review discusses species differences in relation to the effects produced by the neurotoxin 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP); in particular, it focuses on recent evidence regarding the role of excitatory amino acids in experimental parkinsonism. Themain aim of the review is to provide a phylogenetic perspective whichmay serve as a useful tool to study Parkinson's disease in rodents. Excitotoxicity might represent the final common pathway on which the actions of different neurotoxins, selectively directed towards nigrostriatal dompaminergic neurons, converge. This is clearly demonstrated in methamphetamine- and 6-dihydroxy-dopamine-induced parkinsonism. The role of excitotoxicity in the mechanism of action of MPTP is less clear. Although there are several species differences for MPTP it is possible to obtain in mice the same effects induced in MPTP-treated primates by combining acetaldehyde or diethyldithiocarbamate with MPTP administration. When mice are administered these combined treatments, the onset of experimental parkinsonism can be prevented using the same pharmacological agents (i.e. glutamate N-methyl-D-aspartate antagonists) thatare effective in primates. (C) 1997 Elsevier Science Ltd.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 10/07/20 alle ore 03:17:23