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Titolo:
Middle cerebral artery occlusion produces secondary, remote impairment in hippocampal plasticity of rats - involvement of N-methyl-D-aspartate receptors?
Autore:
Sopala, M; Frankiewicz, T; Parsons, C; Danysz, W;
Indirizzi:
Merz & Co, Dept Pharmacol, D-60318 Frankfurt, Germany Merz & Co Frankfurt Germany D-60318 harmacol, D-60318 Frankfurt, Germany
Titolo Testata:
NEUROSCIENCE LETTERS
fascicolo: 2-3, volume: 281, anno: 2000,
pagine: 143 - 146
SICI:
0304-3940(20000310)281:2-3<143:MCAOPS>2.0.ZU;2-G
Fonte:
ISI
Lingua:
ENG
Soggetto:
ISCHEMIA; ATROPHY; DEFICIT; NEURONS;
Keywords:
middle cerebral artery occlusion; hippocampus; long-term-potentiation; N-methyl-D-aspartate receptor antagonist; rat;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
20
Recensione:
Indirizzi per estratti:
Indirizzo: Frankiewicz, T Merz & Co, Dept Pharmacol, Eckenheimer Landstr 100-104, D-60318 Frankfurt,Germany Merz & Co Eckenheimer Landstr 100-104 Frankfurt Germany D-60318
Citazione:
M. Sopala et al., "Middle cerebral artery occlusion produces secondary, remote impairment in hippocampal plasticity of rats - involvement of N-methyl-D-aspartate receptors?", NEUROSCI L, 281(2-3), 2000, pp. 143-146

Abstract

There is increasing evidence that focal cerebral ischaemia produces remotefunctional alterations that may substantially contribute to the post-stroke neurological outcome. Changes initially limited to peri-infarct areas mayevolve and spread via transneuronal connections to other structures. In the present study we investigated whether focal ischaemia produced by 2-h occlusion of the middle cerebral artery (MCAo) in SD; rats may influence the physiological function of the hippocampus. Th ree days later in vitro long-term potentiation (LTP) was studied in hippocampal slices from ipsi- and contralateral hemispheres. In rats with MCAo LTP was not-inducible in the ipsilateral hippocampus, while the contralateral side expressed stable potentiation (6.6 +/- 4.1 vs. 35.0 +/- 8.0%, respectively). Treatment with 6-h i.v.infusion of an uncompetitive N-methyl-D-aspartate (NMDA) receptor antagonist MRZ 2/579 starting at reperfusion not only preserved but additionally enhanced ipsilateral LTP, while a slight insignificant decrease was observed in the contralateral side (77.0 +/- 18.4 vs. 20.8 +/- 6.5%). The study demonstrates post-stroke functional changes in the hippocampus that can be modulated by NMDA receptor antagonists. (C) 2000 Elsevier Science Ireland Ltd. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/06/20 alle ore 01:26:29