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Titolo:
Mutant mice lacking ryanodine receptor type 3 exhibit deficits of contextual fear conditioning and activation of calcium/calmodulin-dependent proteinkinase II in the hippocampus
Autore:
Kouzu, Y; Moriya, T; Takeshima, H; Yoshioka, T; Shibata, S;
Indirizzi:
Waseda Univ, Sch Human Sci, Dept Pharmacol & Brain Sci, Tokorozawa, Saitama 3591192, Japan Waseda Univ Tokorozawa Saitama Japan 3591192 zawa, Saitama 3591192, Japan Waseda Univ, Sch Human Sci, ARCHS, Tokorozawa, Saitama 3591192, Japan Waseda Univ Tokorozawa Saitama Japan 3591192 zawa, Saitama 3591192, Japan Waseda Univ, Sch Human Sci, Dept Mol Neurobiol, Tokorozawa, Saitama 3591192, Japan Waseda Univ Tokorozawa Saitama Japan 3591192 zawa, Saitama 3591192, Japan Univ Tokyo, Fac Med, Dept Pharmacol, Tokyo 113, Japan Univ Tokyo Tokyo Japan 113 yo, Fac Med, Dept Pharmacol, Tokyo 113, Japan
Titolo Testata:
MOLECULAR BRAIN RESEARCH
fascicolo: 1, volume: 76, anno: 2000,
pagine: 142 - 150
SICI:
0169-328X(20000310)76:1<142:MMLRRT>2.0.ZU;2-9
Fonte:
ISI
Lingua:
ENG
Soggetto:
LONG-TERM POTENTIATION; CA2+ RELEASE CHANNELS; CALCIUM-RELEASE; RABBIT BRAIN; CAM-KII; RAT; INDUCTION; NEURONS; LTP; MECHANISMS;
Keywords:
ryanodine receptor; fear conditioning; Ca2+/calmodulin-dependent protein kinase II; hippocampus; knockout mouse; memory;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
49
Recensione:
Indirizzi per estratti:
Indirizzo: Shibata, S Waseda Univ, Sch Human Sci, Dept Pharmacol & Brain Sci, 2-579-15 Mikajima,Tokorozawa, Saitama 3591164, Japan Waseda Univ 2-579-15 MikajimaTokorozawa Saitama Japan 3591164
Citazione:
Y. Kouzu et al., "Mutant mice lacking ryanodine receptor type 3 exhibit deficits of contextual fear conditioning and activation of calcium/calmodulin-dependent proteinkinase II in the hippocampus", MOL BRAIN R, 76(1), 2000, pp. 142-150

Abstract

As it is known that ryanodine receptor type 3 is expressed in the hippocampus, we examined the contribution of this receptor to contextual fear conditioning behavior and to the activation of Ca2+/calmodulin-dependent proteinkinase II using mice lacking the receptor. Ryanodine receptor type 3-deficient mice exhibited impairments of performance in the contextual fear conditioning test, passive avoidance test, and Y-maze learning test. Both the activities of Ca2+/calmodulin-dependent protein kinase II beta and Ca2+/calmodulin-dependent protein kinase II alpha were significantly increased in theexperimental group compared to the control group in the hippocampus, but not in the cingulate cortex on the testing day 24 h after contextual fear training. However, the activities of Ca2+/calmodulin-dependent protein kinaseII beta and alpha were almost the same in the experimental and control groups in the hippocampus on the training day. Ryanodine receptor type 3-deficient mice did not show the increment of Ca2+/calmodulin-dependent protein kinase II beta and alpha activities in the hippocampus on the testing day. In addition, these mutant mice showed the reduction of fear response in the elevated plus-maze test. The present results suggest that calcium-induced calcium release through the activation of ryanodine receptor type 3 in the hippocampus is important to the expression of the performance of contextual learning through the elevation of Ca2+/calmodulin-dependent protein kinase II beta and alpha activities. (C) 2000 Elsevier Science B.V. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 11/07/20 alle ore 03:45:12