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Titolo:
Evidence of relaxant effect of omeprazole in rabbit corpus cavernosum in vitro
Autore:
Sarioglu, Y; Yildirim, S; Utkan, T; Yildirim, MK; Uma, S;
Indirizzi:
Cumhuriyet Univ, Fac Med, Dept Pharmacol, TR-58140 Sivas, Turkey Cumhuriyet Univ Sivas Turkey TR-58140 Pharmacol, TR-58140 Sivas, Turkey Univ Kocaeli, Fac Med, Dept Pharmacol, TR-41900 Kocaeli, Turkey Univ Kocaeli Kocaeli Turkey TR-41900 Pharmacol, TR-41900 Kocaeli, Turkey Univ Hacettepe, Fac Pharm, Dept Pharmacol, TR-06100 Ankara, Turkey Univ Hacettepe Ankara Turkey TR-06100 Pharmacol, TR-06100 Ankara, Turkey
Titolo Testata:
LIFE SCIENCES
fascicolo: 15, volume: 66, anno: 2000,
pagine: 1411 - 1421
SICI:
0024-3205(20000303)66:15<1411:EOREOO>2.0.ZU;2-7
Fonte:
ISI
Lingua:
ENG
Soggetto:
CORPORA CAVERNOSA; MUSCLE; ATPASE; PENIS; PUMP;
Keywords:
corpus cavernosum; H+-K(+)ATPase inhibitors; omeprazole; smooth muscle;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
15
Recensione:
Indirizzi per estratti:
Indirizzo: Sarioglu, Y Cumhuriyet Univ, Fac Med, Dept Pharmacol, TR-58140 Sivas, Turkey Cumhuriyet Univ Sivas Turkey TR-58140 TR-58140 Sivas, Turkey
Citazione:
Y. Sarioglu et al., "Evidence of relaxant effect of omeprazole in rabbit corpus cavernosum in vitro", LIFE SCI, 66(15), 2000, pp. 1411-1421

Abstract

The present experiments were designed to investigate the effects of omeprazole, a H+-K+ ATPase inhibitor, on corporal smooth muscle tone in vitro. All spontaneous contractile activity in the corpus cavernosum was blocked following omeprazole (0.1 mM-1 mM) administration. However atropine (1 mu M), N-w-nitro L-arginine methyl ester (L-NAME, 30 mu M) or indomethacin (10 mu M) did not affect the spontaneous contraction. Omeprazole (10 mu M-1 mM) concentration-dependently induced relaxation in corporal smooth muscle precontracted with 10 mu M phenylephrine or 80 mM KCI. Pretreatment of corporal tissue with L-NAME (30 mu M) indomethacin (10 mu M), ammonium chloride (7.5 mM), sodium acetate (7.5 mM), tetraethyl ammonium chloride (0.5 mM) or glibenclamide (1 mu M) had no effect on the omeprazole induced relaxant responses. Nimodipine, an L-type Ca++ channel blocker relaxed corporal strips precontracted with 80 mM KCI. Collectively, these results indicate that the inhibition of spontaneous Contraction and the relaxation of precontracted corporal smooth muscle by omeprazole is probably mediated by the blockade of calcium channels. Further work is needed to determine the cellular mechanism(s) of action by which omeprazole acts on corpus cavernosum smooth muscle.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/11/20 alle ore 08:55:21