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Titolo:
Blockade of angiotensin II type 1 receptors: Effect on carotid and radial artery structure and function in hypertensive humans
Autore:
Benetos, A; Gautier, S; Lafleche, A; Topouchian, J; Frangin, G; Girerd, X; Sissmann, J; Safar, ME;
Indirizzi:
Hop Broussais, Dept Internal Med, F-75674 Paris 14, France Hop Broussais Paris France 14 ept Internal Med, F-75674 Paris 14, France Hop Broussais, INSERM, U337, F-75674 Paris, France Hop Broussais Paris France F-75674 , INSERM, U337, F-75674 Paris, France
Titolo Testata:
JOURNAL OF VASCULAR RESEARCH
fascicolo: 1, volume: 37, anno: 2000,
pagine: 8 - 15
SICI:
1018-1172(200001/02)37:1<8:BOAIT1>2.0.ZU;2-5
Fonte:
ISI
Lingua:
ENG
Soggetto:
CONVERTING-ENZYME-INHIBITION; LARGE CONDUIT ARTERIES; SMOOTH-MUSCLE CELLS; DELETION POLYMORPHISM; AORTIC COLLAGEN; RATS; GENE; HYPERTROPHY; IRBESARTAN; ENALAPRIL;
Keywords:
hypertension; large-artery structure and function; AT(1)-receptor blockade;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
32
Recensione:
Indirizzi per estratti:
Indirizzo: Safar, ME Hop Broussais, Dept Internal Med, 96 Rue Didot, F-75674 Paris 14, France Hop Broussais 96 Rue Didot Paris France 14 674 Paris 14, France
Citazione:
A. Benetos et al., "Blockade of angiotensin II type 1 receptors: Effect on carotid and radial artery structure and function in hypertensive humans", J VASC RES, 37(1), 2000, pp. 8-15

Abstract

Converting-enzyme inhibition reduces cardiovascular hypertrophy in hypertensive subjects. Whether the blockade of angiotensin II type 1 (AT(1)) receptors reduces arterial hypertrophy has never been investigated. In a double-blind study versus placebo in subjects with essential hypertension, the effect of the AT(1) blocker irbesartan (150 mg/day for 8 weeks) on blood pressure, wall thickness, diameter and stiffness of the common carotid and radial arteries was studied, using echotracking techniques of high resolution. With irbesartan, mean blood pressure decreased significantly and proportionally to the baseline levels of active renin, and angiotensin I and II. Therewas a significant decrease in radial artery wall thickness. The percent change from baseline (+/- SEM) was -10.51 +/- 3.42 versus 6.18 +/- 4.77. There was no significant change in diameter or distensibility. This effect was correlated neither to blood pressure changes nor to hormonal baseline levels of the renin-angiotensin system. Carotid wall thickness and diameter wereunchanged. Thus a 2-month treatment with an AT(1) antagonist significantlyreduced radial but not carotid artery wall thickness. Blood pressure reduction could be explained on the basis of circulating renin-angiotensin activity. On the contrary, radial artery wall thickness reduction was independent of the baseline circulating renin-angiotensin activity and was not correlated with the effects of AT(1) blockade on blood pressure, thus implying the involvement of local hemodynamic and/or cellular mechanisms. Copyright (C)2000 S. Karger AG, Basel.

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Documento generato il 01/04/20 alle ore 17:13:58