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Titolo:
Local delivery of nadroparin via hydrogel-coated angioplasty balloon: Effect on platelet deposition and smooth muscle cell proliferation - An experimental study
Autore:
Johnson, MS; Bergmann, CA; Carmody, TJ; Dreesen, RG; Barry, JJ; Barina, C; Orazi, A; Ambrosius, WT;
Indirizzi:
Indiana Univ, Sch Med, Dept Radiol, Indianapolis, IN 46202 USA Indiana Univ Indianapolis IN USA 46202 Radiol, Indianapolis, IN 46202 USA Indiana Univ, Sch Med, Dept Pathol & Lab Med, Indianapolis, IN 46202 USA Indiana Univ Indianapolis IN USA 46202 ab Med, Indianapolis, IN 46202 USA Indiana Univ, Sch Med, Dept Med, Indianapolis, IN 46202 USA Indiana Univ Indianapolis IN USA 46202 pt Med, Indianapolis, IN 46202 USA Boston Sci Corp, Natick, MA USA Boston Sci Corp Natick MA USABoston Sci Corp, Natick, MA USA
Titolo Testata:
JOURNAL OF VASCULAR AND INTERVENTIONAL RADIOLOGY
fascicolo: 1, volume: 11, anno: 2000,
pagine: 115 - 122
SICI:
1051-0443(200001)11:1<115:LDONVH>2.0.ZU;2-5
Fonte:
ISI
Lingua:
ENG
Soggetto:
MOLECULAR-WEIGHT HEPARIN; FIBROBLAST GROWTH-FACTOR; ENDOTHELIAL INJURY; TISSUE-SECTIONS; DRUG-DELIVERY; TIME-COURSE; PREVENTION; INHIBITION; PHARMACOLOGY; MITOGENESIS;
Keywords:
angioplasty; drug delivery systems; heparin; smooth muscle cells;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
31
Recensione:
Indirizzi per estratti:
Indirizzo: Johnson, MS Indiana Univ, Sch Med, Indiana Univ Hosp 0279, 550 N Univ Blvd, Indianapolis, IN 46202 USA Indiana Univ 550 N Univ Blvd Indianapolis IN USA 46202 202 USA
Citazione:
M.S. Johnson et al., "Local delivery of nadroparin via hydrogel-coated angioplasty balloon: Effect on platelet deposition and smooth muscle cell proliferation - An experimental study", J VAS INT R, 11(1), 2000, pp. 115-122

Abstract

PURPOSE: To assess the feasibility of intravascular delivery of nadroparin, a low-molecular-weight heparin, via hydrogel-coated angioplasty balloons,and the effects of nadroparin delivered in this manner on platelet deposition and smooth muscle cell (SMC) proliferation,MATERIALS AND METHODS: Tritiated nadroparin was used to determine the nadroparin-carrying capacity of the hydrogel-coating, kinetics of release from the balloons, and, in four pigs, delivery of the nadroparin to the iliac arterial wall. Platelet deposition in nadroparin-treated iliac arteries versus contralateral iliac arteries dilated with saline-loaded, hydrogel-coated balloons was quantified in seven pigs using (111)Indium-labeled platelets. Smooth muscle cell proliferation in nadroparin and saline-treated iliac arteries in 10 pigs was evaluated 7 days after angioplasty with use of proliferating cell nuclear antigen. RESULTS: Approximately 98 international units of nadroparin were deliveredby the hydrogel-coated balloon, the majority to the angioplasty site and distal vessel. There was a trend toward decreased platelet deposition in nadroparin-treated arteries, but statistical significance was not achieved (P = .1563). Medial SMC proliferation was decreased in the nadroparin-treated arteries in nine of 10 pigs (P = .0137). CONCLUSIONS: Hydrogel-coated balloons may be used to deliver nadroparin tothe arterial wall, with measurable levels of the drug delivered to the site of angioplasty, and with resultant decrease in SMC proliferation.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 14/07/20 alle ore 19:28:05