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Titolo:
Antipsychotic agents and QT changes
Autore:
Welch, R; Chue, P;
Indirizzi:
Univ Alberta, Psychopharmacol Res Unit, Edmonton, AB T6G 2B7, Canada Univ Alberta Edmonton AB Canada T6G 2B7 nit, Edmonton, AB T6G 2B7, Canada Alberta Hosp, Edmonton, AB, Canada Alberta Hosp Edmonton AB CanadaAlberta Hosp, Edmonton, AB, Canada
Titolo Testata:
JOURNAL OF PSYCHIATRY & NEUROSCIENCE
fascicolo: 2, volume: 25, anno: 2000,
pagine: 154 - 160
SICI:
1180-4882(200003)25:2<154:AAAQC>2.0.ZU;2-T
Fonte:
ISI
Lingua:
ENG
Soggetto:
HAY-FEVER DRUG; DE-POINTES; CRITICALLY ILL; INTERVAL; PROLONGATION; HALOPERIDOL; SCHIZOPHRENIA; RISPERIDONE; EXPRESSION; SEVERITY;
Keywords:
action potentials; antipsychotic agents; arrhythmia; death; sudden; electrocardiography; ion channels; torsades de pointes;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Social & Behavioral Sciences
Citazioni:
52
Recensione:
Indirizzi per estratti:
Indirizzo: Chue, P Univ Alberta, Psychopharmacol Res Unit, 10-126 CSB,8440-112th St, Edmonton, AB T6G 2B7, Canada Univ Alberta 10-126 CSB,8440-112th St EdmontonAB Canada T6G 2B7 a
Citazione:
R. Welch e P. Chue, "Antipsychotic agents and QT changes", J PSYCH NEU, 25(2), 2000, pp. 154-160

Abstract

Recently antipsychotic medications of the novel or atypical classes have received increased: attention because of concerns with respect to potential lengthening of the QT interval, yet the currently available I and commonly prescribed conventional antipsychotics are significantly more cardiotoxic, particularly agents in the butyrophenone and phenothiazine classes. Lengthening of the QT interval can be associated with a I fatal paroxysmal ventricular arrhythmia known as torsades de pointes. The specific duration of the QT interval at which the risk of an adverse cardiac event is greatest, is not established. There is not only significant variation in the applied definition of an abnormal interval, but the maximal QT interval in healthy volunteers is greater than the currently accepted standards. The QT interval isinfluenced by normal physiological and pathologic factors, but the mechanisms remain unclear. Using recombinant technology, haloperidol and sertindole have been demonstrated to be high-affinity antagonists of a human cardiacpotassium channel encoded by the human ether-a-go-go-related gene. Pimozide, however, has been shown to act principally through calcium channel antagonism, and chlorpromazine may affect sodium channels. Nevertheless, it is possible that these effects are significant only in the presence of predisposing factors, either genetic or acquired. Despite proven efficacy in clinical trials and subsequent supervised use in Europe, a number of recently developed antipsychotic medications are not available to patients in North America. Yet conventional antipsychotic medications that would not be approvedby current safety standards continue to be widely used.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 02/04/20 alle ore 00:19:41