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Titolo:
Novel antipsychotics: issues and controversies. Typicality of atypical antipsychotics
Autore:
Stip, E;
Indirizzi:
Univ Montreal, Hop L H Lafontaine, Ctr Rech Fernand Seguin, Montreal, PQ, Canada Univ Montreal Montreal PQ Canada ch Fernand Seguin, Montreal, PQ, Canada Univ British Columbia, Vancouver, BC V5Z 1M9, Canada Univ British Columbia Vancouver BC Canada V5Z 1M9 ver, BC V5Z 1M9, Canada
Titolo Testata:
JOURNAL OF PSYCHIATRY & NEUROSCIENCE
fascicolo: 2, volume: 25, anno: 2000,
pagine: 137 - 153
SICI:
1180-4882(200003)25:2<137:NAIACT>2.0.ZU;2-P
Fonte:
ISI
Lingua:
ENG
Soggetto:
TREATMENT-RESISTANT SCHIZOPHRENIA; D2-DOPAMINE RECEPTOR OCCUPANCY; DOUBLE-BLIND; NEGATIVE SYMPTOMS; ACOUSTIC STARTLE; DOPAMINE D-2; LONG-TERM; ELECTROPHYSIOLOGICAL PROFILE; SCHIZOAFFECTIVE DISORDER; REFRACTORY SCHIZOPHRENIA;
Keywords:
antipsychotic agents; clozapine; cognition; receptors; dopamine; risperidone; schizophrenia;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Social & Behavioral Sciences
Citazioni:
170
Recensione:
Indirizzi per estratti:
Indirizzo: Stip, E Ctr Rech Fernand Seguin, 7331 Hochelaga, Montreal, PQ H1N 3V2, Canada Ctr Rech Fernand Seguin 7331 Hochelaga Montreal PQ Canada H1N 3V2
Citazione:
E. Stip, "Novel antipsychotics: issues and controversies. Typicality of atypical antipsychotics", J PSYCH NEU, 25(2), 2000, pp. 137-153

Abstract

The typicality of atypical antipsychotic drugs remains debatable. Preclinical studies and findings from randomized, controlled and open trials of clozapine, olanzapine, risperidone, quetiapine, sertindole, ziprasidone and a substituted benzamide were examined. A MEDLINE search was conducted using key words, including "extrapyramidal side effects," "cognition," "schizophrenia" and the generic drug names. Over 140 articles from peer-reviewed journals were reviewed, some of which were based on a meta-analysis. New-generation neuroleptic agents were found to have greater efficacy on the negative symptoms of schizophrenia and to cause fewer unwanted extrapyramidal side effects (EPS) than the traditional antipsychotic drugs. On one hand, atypical neuroleptic agents could be strictly defined as any neuroleptic agent with antipsychotic effects at a dosage that does not cause extrapyramidal sideeffects. Thus, clozapine is regarded as the "standard" atypical antipsychotic drug. On the other hand, typicality is about dimension rather than category, and we suggest the use of the term "spectrum of atypicality. " For example, an emphasis is placed on quetiapine to illustrate where a new compound fits in this spectrum. Although dose-related, atypicality may be more a question of prescription attitude than of a specific characteristic of a compound. The degree to which a new compound is clinically superior to anotheratypical antipsychotic drug, in terms of improving positive, negative or affective symptoms, cognitive function and long-term outcome, will require further a priori hypotheses based on conceptual frameworks that are clinically meaningful. In addition, the results from industry-sponsored trials should be more comparable to those obtained from investigator-leading trials. Finally, the patient characteristics that define a patient's response to a specific antipsychotic drug are unknown.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 27/01/20 alle ore 14:04:01