Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
A comparison of iron availability from commercial iron preparations using an in vitro digestion/Caco-2 cell culture model
Autore:
Glahn, RP; Rassier, M; Goldman, MI; Lee, OA; Cha, J;
Indirizzi:
Cornell Univ, USDA ARS, US Plant Soil & Nutr Lab, Ithaca, NY 14853 USA Cornell Univ Ithaca NY USA 14853 nt Soil & Nutr Lab, Ithaca, NY 14853 USA Marshfield Clin, Minocqua, WI USA Marshfield Clin Minocqua WI USAMarshfield Clin, Minocqua, WI USA
Titolo Testata:
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
fascicolo: 2, volume: 11, anno: 2000,
pagine: 62 - 68
SICI:
0955-2863(200002)11:2<62:ACOIAF>2.0.ZU;2-Z
Fonte:
ISI
Lingua:
ENG
Soggetto:
FERROUS SULFATE; HEME-IRON; ABSORPTION; CALCIUM; SUPPLEMENTATION; BIOAVAILABILITY; FORTIFICATION; COMPLEX;
Keywords:
iron; availability; calcium acetate; calcium carbonate; Caco-2;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Agriculture,Biology & Environmental Sciences
Life Sciences
Citazioni:
20
Recensione:
Indirizzi per estratti:
Indirizzo: Glahn, RP Cornell Univ, USDA ARS, US Plant Soil & Nutr Lab, Tower Rd, Ithaca, NY 14853 USA Cornell Univ Tower Rd Ithaca NY USA 14853 , Ithaca, NY 14853 USA
Citazione:
R.P. Glahn et al., "A comparison of iron availability from commercial iron preparations using an in vitro digestion/Caco-2 cell culture model", J NUTR BIOC, 11(2), 2000, pp. 62-68

Abstract

The objectives of this study were to compare iron availability from commercial preparations of FeSO4, ferrous gluconate, ferrous fumarate, and a polysaccharide-iron complex using an in vitro digestion/Caco-2 cell culture model. In addition, we sought to determine if calcium carbonate and calcium acetate (common phosphate binding agents) inhibited iron availability from anoral iron supplement when digested simultaneously. Caco-2 cell ferritin formation following exposure to simulated gastric and intestinal digests of the iron supplements was used as a measure of iron uptake and availability. Plates without cell monolayers were included in each replication of the experiment to measure the total amount of soluble iron that resulted from the in vitro digestion. Significantly more iron was taken up from the FeSO4, ferrous gluconate, and ferrous fumarate than the polysaccharide-iron complex. Similar results comparing FeSO4 and the polysaccharide-iron complex have been observed in humans. In addition, less iron was taken up from digests with calcium carbonate relative to calcium acetate even though similar amounts of soluble iron were observed in these experiments. The results indicate that when iron supplements and phosphate binders are consumed simultaneously, calcium acetate may be the preferred phosphate binder to maximize iron availability. (J. Nutr. Biochem. 11:62-68, 2000) (C) Elsevier Science Inc. 2000. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/11/20 alle ore 15:57:20