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Titolo:
Interaction among mitochondria, mitogen-activated protein kinases, and nuclear factor-kappa B in cellular models of Parkinson's disease
Autore:
Cassarino, DS; Halvorsen, EM; Swerdlow, RH; Abramova, NN; Parker, WD; Sturgill, TW; Bennett, JP;
Indirizzi:
Univ Virginia, Hlth Sci Ctr, Dept Neurol, Charlottesville, VA 22908 USA Univ Virginia Charlottesville VA USA 22908 Charlottesville, VA 22908 USA Univ Virginia, Hlth Sci Ctr, Ctr Study Neuordegenerat Dis, Charlottesville, VA 22908 USA Univ Virginia Charlottesville VA USA 22908 Charlottesville, VA 22908 USA Univ Virginia, Hlth Sci Ctr, Markey Ctr Cell Signaling, Charlottesville, VA 22908 USA Univ Virginia Charlottesville VA USA 22908 Charlottesville, VA 22908 USA Univ Virginia, Hlth Sci Ctr, Dept Pharmacol, Charlottesville, VA 22908 USAUniv Virginia Charlottesville VA USA 22908 Charlottesville, VA 22908 USA Univ Virginia, Hlth Sci Ctr, Dept Behav Med, Charlottesville, VA 22908 USAUniv Virginia Charlottesville VA USA 22908 Charlottesville, VA 22908 USA Univ Virginia, Hlth Sci Ctr, Dept Internal Med, Charlottesville, VA 22908 USA Univ Virginia Charlottesville VA USA 22908 Charlottesville, VA 22908 USA Univ Virginia, Hlth Sci Ctr, Howard Hughes Med Inst, Charlottesville, VA 22908 USA Univ Virginia Charlottesville VA USA 22908 Charlottesville, VA 22908 USA
Titolo Testata:
JOURNAL OF NEUROCHEMISTRY
fascicolo: 4, volume: 74, anno: 2000,
pagine: 1384 - 1392
SICI:
0022-3042(200004)74:4<1384:IAMMPK>2.0.ZU;2-5
Fonte:
ISI
Lingua:
ENG
Soggetto:
OXIDATIVE STRESS; SIGNAL-TRANSDUCTION; INDUCED APOPTOSIS; DEATH; JNK; PATHWAYS; NEURONS; CELLS; ALPHA; MEKK1;
Keywords:
oxidative stress; mitochondria; mitogen-activated protein kinases; nuclear factor-kappa B; Parkinson's disease; stress-activated protein kinase; c-Jun terminal kinase; electron transport chain; adenine nucleotide translocator;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
49
Recensione:
Indirizzi per estratti:
Indirizzo: Bennett, JP Univ Virginia, Hlth Sci Ctr, Dept Neurol, Box 394, Charlottesville, VA 22908 USA Univ Virginia Box 394 Charlottesville VA USA 22908 A 22908 USA
Citazione:
D.S. Cassarino et al., "Interaction among mitochondria, mitogen-activated protein kinases, and nuclear factor-kappa B in cellular models of Parkinson's disease", J NEUROCHEM, 74(4), 2000, pp. 1384-1392

Abstract

Oxidative stress induced by acute complex I inhibition with 1-methyl-4-phenylpyridinium ion activated biphasically the stress-activated c-Jun N-terminal kinase (JNK) and the early transcription factor nuclear factor-kappa B (NF-kappa B) in SH-SY5Y neuroblastoma cells. Early JNK activation was dependent on mitochondrial adenine nucleotide translocator (ANT) activity, whereas late-phase JNK activation and the cleavage of signaling proteins Raf-1 and mitogen-activated protein kinase (MAPK) kinase (MEK) kinase (MEKK)-1 appeared to be ANT-independent. Early NF-kappa B activation depended on MEK, later activation required an intact electron transport chain (ETC), and Parkinson's disease (PD) cybrid (mitochondrial transgenic cytoplasmic hybrid) cells had increased basal NF-kappa B activation. Mitochondria appear capableof signaling ETC impairment through MAPK modules and inducing protective NF-kappa B responses, which are increased by PD mitochondrial genes amplified in cybrid cells. Irreversible commitment to apoptosis in this cell model may derive from loss of Raf-1 and cleavage/activation of MEKK-1, processes reported in other models to be caspase-mediated. Therapeutic strategies that reduce mitochondrial activation of proapoptotic MAPK modules, i.e., JNK, and enhance survival pathways, i.e., NF-kappa B, may offer neuroprotection in this debilitating disease.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 22/01/20 alle ore 12:52:35