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Titolo:
Interaction between the serotoninergic and dopaminergic systems in d-fenfluramine-induced activation of c-fos and jun B genes in rat striatal neurons
Autore:
Gardier, AM; Moratalla, R; Cuellar, B; Sacerdote, M; Guibert, B; Lebrec, H; Graybiel, AM;
Indirizzi:
CSIC, Inst Cajal Neurobiol, Madrid 28002, Spain CSIC Madrid Spain 28002CSIC, Inst Cajal Neurobiol, Madrid 28002, Spain Univ Paris Sud, Fac Pharm, IFR ISIT, Lab Neuropharmacol UPRES EAD MENRT, Chatenay Malabry, France Univ Paris Sud Chatenay Malabry France MENRT, Chatenay Malabry, France Univ Paris Sud, Fac Pharm, IFR ISIT, Lab Toxicol,INSERM,U461, Chatenay Malabry, France Univ Paris Sud Chatenay Malabry France M,U461, Chatenay Malabry, France Univ Picardie, Fac Pharm, Pharmacol Lab, Amiens, France Univ Picardie Amiens France e, Fac Pharm, Pharmacol Lab, Amiens, France MIT, Dept Brain & Cognit Sci, Cambridge, MA 02139 USA MIT Cambridge MA USA 02139 pt Brain & Cognit Sci, Cambridge, MA 02139 USA
Titolo Testata:
JOURNAL OF NEUROCHEMISTRY
fascicolo: 4, volume: 74, anno: 2000,
pagine: 1363 - 1373
SICI:
0022-3042(200004)74:4<1363:IBTSAD>2.0.ZU;2-K
Fonte:
ISI
Lingua:
ENG
Soggetto:
BRAIN-SEROTONIN; UPTAKE SITES; RECEPTOR ANTAGONISTS; MATRIX COMPARTMENTS; NUCLEUS-ACCUMBENS; INDUCED ANOREXIA; CEREBRAL-CORTEX; CONSCIOUS RATS; RELEASE INVIVO; EXPRESSION;
Keywords:
dexfenfluramine; striatum; c-fos; jun B; dynorphin; p-chloroamphetamine;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
57
Recensione:
Indirizzi per estratti:
Indirizzo: Moratalla, R CSIC, Inst Cajal Neurobiol, Dr Arce 37, Madrid 28002, Spain CSIC Dr Arce 37 Madrid Spain 28002 e 37, Madrid 28002, Spain
Citazione:
A.M. Gardier et al., "Interaction between the serotoninergic and dopaminergic systems in d-fenfluramine-induced activation of c-fos and jun B genes in rat striatal neurons", J NEUROCHEM, 74(4), 2000, pp. 1363-1373

Abstract

To test for the relative contributions of the dopaminergic and serotoninergic systems in the striatum to the effects of d-fenfluramine, an indirect serotonin receptor agonist, we assessed the expression of Fos/Jun proteins induced by d-fenfluramine given alone or in the presence of dopaminergic or serotoninergic agents. To determine the neuronal targets of d-fenfluramine in the striatum, we identified the phenotypes of striatal neurons in which d-fenfluramine induced Fos expression. Our results demonstrated that d-fenfluramine evokes nuclear expression of Fos/Jun B proteins in the striatum, and that the Fos expression was dose-dependent and accompanied by transient induction of c-fos mRNA. Fos expression was blocked by p-chloroamphetamine,a serotoninergic neurotoxin. Pretreatment with SCH 23390, a D-1-dopamine receptor antagonist, led to a marked decrease in Fos/Jun B expression in thecaudoputamen, but not in the cortex, whereas pretreatment with methiothepin, a nonselective serotonin 5-HT1 receptor antagonist, blocked Fos expression completely in the cortex and only partially in the caudoputamen, The expression of Fos/Jun B in the striatum occurred mainly in dynorphin-containing neurons and in a subpopulation of striatal interneurons that exhibited NADPH-diaphorase activity. Most of the enkephalin-containing neurons of the striatum did not show Fos/Jun B staining. These results suggest that the mechanism by which d-fenfluramine induces c-fos and jun B expression in the rat caudoputamen depends at least in part on activation of the dopaminergic system by serotonin.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 02/04/20 alle ore 02:27:42