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Titolo:
Oral vaccine delivery
Autore:
Russell-Jones, GJ;
Indirizzi:
Biotech Australia Pty Ltd, Roseville, NSW 2069, Australia Biotech Australia Pty Ltd Roseville NSW Australia 2069 SW 2069, Australia
Titolo Testata:
JOURNAL OF CONTROLLED RELEASE
fascicolo: 1-2, volume: 65, anno: 2000,
pagine: 49 - 54
SICI:
0168-3659(20000301)65:1-2<49:OVD>2.0.ZU;2-3
Fonte:
ISI
Lingua:
ENG
Soggetto:
HEAT-LABILE ENTEROTOXIN; PHASEOLUS-VULGARIS LECTINS; RAT SMALL-INTESTINE; B SURFACE-ANTIGEN; TRANSGENIC PLANTS; CHOLERA-TOXIN; EPITHELIAL-CELLS; SUBUNIT; IMMUNIZATION; IDENTIFICATION;
Keywords:
oral vaccine; mucosal immunity; systemic immunity; immune response;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
38
Recensione:
Indirizzi per estratti:
Indirizzo: Russell-Jones, GJ Biotech Australia Pty Ltd, POB 20, Roseville, NSW 2069, Australia Biotech Australia Pty Ltd POB 20 Roseville NSW Australia 2069
Citazione:
G.J. Russell-Jones, "Oral vaccine delivery", J CONTR REL, 65(1-2), 2000, pp. 49-54

Abstract

Oral vaccination of animals and man, to provide effective mucosal and/or systemic immunity, is largely ineffective. This is due mainly to the very small quantity of antigen that survives degradation in the intestine and thatcrosses the intestinal wall. Over the past decade or so, a number of proteins have been identified that are effective at eliciting mucosal and systemic immune responses following oral administration. Uptake of these molecules by the gastro-intestinal tract (GIT) epithelium is dependent upon specific binding to the GIT epithelial cells. The identity of these molecules is discussed, as well as their possible application as 'carriers' for co-transporting haptens. proteins and nanoparticles across the GIT epithelium. (C) 2000 Elsevier Science B.V. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/12/20 alle ore 03:07:14