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Titolo:
Muscle changes in the neuroleptic malignant syndrome
Autore:
Behan, WMH; Madigan, M; Clark, BJ; Goldberg, J; McLellan, DR;
Indirizzi:
Univ Glasgow, Western Infirm, Dept Pathol, Glasgow G11 6NT, Lanark, Scotland Univ Glasgow Glasgow Lanark Scotland G11 6NT ow G11 6NT, Lanark, Scotland Victoria Infirm, Dept Surg, Glasgow G42 9TY, Lanark, Scotland Victoria Infirm Glasgow Lanark Scotland G42 9TY G42 9TY, Lanark, Scotland Victoria Infirm, Dept Pathol, Glasgow G42 9TY, Lanark, Scotland Victoria Infirm Glasgow Lanark Scotland G42 9TY G42 9TY, Lanark, Scotland
Titolo Testata:
JOURNAL OF CLINICAL PATHOLOGY
fascicolo: 3, volume: 53, anno: 2000,
pagine: 223 - 227
SICI:
0021-9746(200003)53:3<223:MCITNM>2.0.ZU;2-9
Fonte:
ISI
Lingua:
ENG
Soggetto:
MDMA ECSTASY; HYPERTHERMIA; PATHOLOGY; DEATHS; HYPERPYREXIA; EVE;
Keywords:
myopathy; neuroleptic malignant syndrome; fluoxetine; remoxipride hydrochloride monohydrate; Ecstasy; LSD;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
31
Recensione:
Indirizzi per estratti:
Indirizzo: Behan, WMH Univ Glasgow, Western Infirm, Dept Pathol, Dumbarton Rd, Glasgow G11 6NT, Lanark, Scotland Univ Glasgow Dumbarton Rd Glasgow Lanark Scotland G11 6NT tland
Citazione:
W.M.H. Behan et al., "Muscle changes in the neuroleptic malignant syndrome", J CLIN PATH, 53(3), 2000, pp. 223-227

Abstract

Aims-To characterise the skeletal muscle changes in the neuroleptic malignant syndrome (NMS). Methods-Detailed light and ultrastructural examination was carried out on skeletal muscle from three cases of NMS, two associated with recreational drugs (3,4-methlenedioxymethylamphetamine ((MDMA, Ecstasy) and lysergic aciddiethylamide (LSD)) and one with antipsychotic drugs (fluoxetine (Prozac) and remoxipride hydrochloride monohydrate (Roxiam)). Results-The muscles were grossly swollen and oedematous in all cases, in one with such severe local involvement that the diagnosis of sarcoma was considered. On microscopy, there was conspicuous oedema. In some fascicles less than 10% of fibres were affected whereas in others more than 50% were pale and enlarged. There was a spectrum of changes: tiny to large vacuoles replaced most of the sarcoplasm and were associated with necrosis. A striking feature in some fibres was the presence of contraction bands separating segments of oedematous myofibrils. Severe endomysial oedema was also detectable. There was a scanty mononuclear infiltrate but no evidence of regeneration. Conclusions-The muscle changes associated with NMS are characteristic and may be helpful in differential diagnosis.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 02/04/20 alle ore 12:57:03