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Titolo:
Endothelial dysfunction in patients with heart failure: Relationship to disease severity
Autore:
Bank, AJ; Lee, PC; Kubo, SH;
Indirizzi:
Univ Minnesota, Dept Med, Div Cardiovasc, Minneapolis, MN 55455 USA Univ Minnesota Minneapolis MN USA 55455 iovasc, Minneapolis, MN 55455 USA
Titolo Testata:
JOURNAL OF CARDIAC FAILURE
fascicolo: 1, volume: 6, anno: 2000,
pagine: 29 - 36
SICI:
1071-9164(200003)6:1<29:EDIPWH>2.0.ZU;2-K
Fonte:
ISI
Lingua:
ENG
Soggetto:
LEFT-VENTRICULAR DYSFUNCTION; CONSCIOUS DOGS; NITRIC-OXIDE; DEPENDENT VASODILATION; MEDIATED VASODILATION; RESISTANCE VESSELS; EXERCISE; CIRCULATION; DILATION; ARTERY;
Keywords:
vasodilation; endothelium; nitric oxide;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
32
Recensione:
Indirizzi per estratti:
Indirizzo: Bank, AJ Univ Minnesota, St Paul Heart Clin, 255 N Smith Ave,Suite 100, StPaul, MN55102 USA Univ Minnesota 255 N Smith Ave,Suite 100 St Paul MN USA 55102 USA
Citazione:
A.J. Bank et al., "Endothelial dysfunction in patients with heart failure: Relationship to disease severity", J CARD FAIL, 6(1), 2000, pp. 29-36

Abstract

Background: Heart failure is associated with abnormal endothelium-dependent vasodilation. However, the relationship of this abnormality to heart failure severity has not been well defined. Methods and Results: We used strain-gauge plethysmography to assess forearm blood flow (FBF) responses to endothelium-dependent, endothelium-independent, and reactive hyperemic stimuli in normal subjects (n = 29) and in patients with mild (n = 26) and severe (n = 41) heart failure. FBF responses tointra-arterial methacholine (0.3, 1.5, 3.0 mu g/min) were significantly (P<.005) and similarly reduced in patients with mild (2.8 +/- 0.4, 5.9 +/- 0.7, and 7.7 +/- 1.1 mL/min/dL) and severe (2.7 +/- 0.4, 5.4 +/- 0.7, and 6.9 +/- 0.9) heart failure compared with normal subjects (4.5 +/- 0.4, 9.4 +/- 1.0, and 12.0 +/- 1.1). FBF responses to nitroprusside (1, 5, 10 mu g/min) were significantly reduced in mild (2.4 +/- 0.3, 6.7 +/- 1.1, and 11.9 +/- 2.0, P <.05) and severe (1.9 +/- 0.2, 5.1 +/- 0.5, and 7.3 +/- 0.9, P <.001) heart failure groups compared with normal subjects (3.8 +/- 0.5, 10.8 +/- 1.2, and 14.9 +/- 1.2). However, FBF responses were reduced to a greaterextent (P <.001) in mild heart failure compared with severe heart failure. Peak reactive hyperemia was significantly impaired only in severe heart failure. There was no correlation between methacholine responses and ejectionfraction, maximum oxygen consumption, wedge pressure, or serum norepinephrine. Conclusion: Impaired endothelium-dependent vasodilation is present and near maximum in mild heart failure. Endothelial dysfunction may be an early finding in human heart failure.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 02/04/20 alle ore 06:26:22