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Titolo:
Improved compression properties of propyphenazone spherical crystals
Autore:
Di Martino, P; Di Cristofaro, R; Barthelemy, C; Joiris, E; Filippo, GP; Sante, M;
Indirizzi:
Fac Farm, Dipartimento Sci Chim, Lab Tecn Farmaceut, I-62032 Camerino, Italy Fac Farm Camerino Italy I-62032 Tecn Farmaceut, I-62032 Camerino, Italy Univ Lille 2, Fac Sci Pharmaceut & Biol, Lab Pharmacotech Off & Ind, F-59006 Lille, France Univ Lille 2 Lille France F-59006 otech Off & Ind, F-59006 Lille, France
Titolo Testata:
INTERNATIONAL JOURNAL OF PHARMACEUTICS
fascicolo: 1-2, volume: 197, anno: 2000,
pagine: 95 - 106
SICI:
0378-5173(20000320)197:1-2<95:ICPOPS>2.0.ZU;2-5
Fonte:
ISI
Lingua:
ENG
Soggetto:
CRYSTALLIZATION TECHNIQUE; 2-SOLVENT SYSTEM; STRENGTH;
Keywords:
propyphenazone; spherical crystallization; compression behavior; brittle fracture;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
24
Recensione:
Indirizzi per estratti:
Indirizzo: Di Martino, P Fac Farm, Dipartimento Sci Chim, Lab Tecn Farmaceut, Via S Agostino, I-62032 Camerino, Italy Fac Farm Via S Agostino Camerino Italy I-62032 erino, Italy
Citazione:
P. Di Martino et al., "Improved compression properties of propyphenazone spherical crystals", INT J PHARM, 197(1-2), 2000, pp. 95-106

Abstract

Spherical propyphenazone crystals were produced by an agglomeration technique using a three solvents system. After selecting the best propyphenazone solvent (ethyl alcohol), non-solvent (demineralized water) and bridging liquid (isopropyl acetate), several of their ratios were tested by a Sheffe ternary diagram. Micromeritic properties of agglomerates such as flowability,were improved and their compression behavior was investigated and comparedto that of raw crystals. By compression and densification studies, along with tablet SEM analysis, we have been able to explain the compression mechanism of propyphenazone spherical crystals and have shown that their better tablet/ability can be due to the small size of individual particles in the agglomerates (C) 2000 Elsevier Science B.V. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 22/01/20 alle ore 12:54:30