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Titolo:
Synapses on human spiral ganglion cells: a transmission electron microscopy and immunohistochemical study
Autore:
Rask-Andersen, H; Tylstedt, S; Kinnefors, A; Illing, RB;
Indirizzi:
Univ Uppsala Hosp, Akad Sjukhuset, Dept Otolaryngol, S-75185 Uppsala, Sweden Univ Uppsala Hosp Uppsala Sweden S-75185 ryngol, S-75185 Uppsala, Sweden Univ Freiburg, Dept Otorhinolaryngol, Neurobiol Res Lab, D-79106 Freiburg,Germany Univ Freiburg Freiburg Germany D-79106 Res Lab, D-79106 Freiburg,Germany
Titolo Testata:
HEARING RESEARCH
fascicolo: 1-2, volume: 141, anno: 2000,
pagine: 1 - 11
SICI:
0378-5955(200003)141:1-2<1:SOHSGC>2.0.ZU;2-2
Fonte:
ISI
Lingua:
ENG
Soggetto:
COCHLEA; INHIBITION;
Keywords:
spiral ganglion; inner ear; electron microscopy; synaptophysin; human;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
25
Recensione:
Indirizzi per estratti:
Indirizzo: Rask-Andersen, H Univ Uppsala Hosp, Akad Sjukhuset, Dept Otolaryngol, S-75185 Uppsala, Sweden Univ Uppsala Hosp Uppsala Sweden S-75185 ppsala, Sweden
Citazione:
H. Rask-Andersen et al., "Synapses on human spiral ganglion cells: a transmission electron microscopy and immunohistochemical study", HEARING RES, 141(1-2), 2000, pp. 1-11

Abstract

A transmission electron microscopy (TEM) study and synaptophysin immunoreactivity analysis of neurons in the human spiral ganglion was performed withparticular emphasis on the demonstration of synapses. The study was based on surgical biopsy material obtained during transcochlear meningioma surgery. Vesiculated nerve endings of unmyelinated nerve fibers occurred frequently on the small ganglion cells at all levels. The nerve terminals exhibitedabundant clear synaptic vesicles but also dense-core vesicles. Multisynaptic contact sites were also seen with fibers of the intraganglionic spiral bundle (IGSB). Complex associations of synapses could be demonstrated, including several synaptic terminals in conjunction with contact sites or an adherent type of junctions on large ganglion cells. These contact sites exhibited membrane densities which were symmetric or asymmetric, changed their polarity recurrently over their extension from one cell to the other and backand lacked clear synaptic vesicles. This suggests the existence of connections between efferents, belonging to the olivocochlear bundle, and both small and large ganglion cells. Thus, both the inner and outer hair cell system may be under the influence of efferent innervation in the human spiral ganglion. The morphology and course of synaptophysin-positive nerve fibers indicated that synaptic contacts within the spiral ganglion, as observed under the electron microscope, may be abundant. These results indicate that complex neural processing may occur at the level of the spiral ganglion in man. (C) 2000 Elsevier Science B.V. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/07/20 alle ore 05:07:46