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Titolo:
Genetic architecture of the polyketide synthases for methymycin and pikromycin series macrolides
Autore:
Xue, YQ; Wilson, D; Sherman, DH;
Indirizzi:
Univ Minnesota, Dept Microbiol, Minneapolis, MN 55455 USA Univ Minnesota Minneapolis MN USA 55455 robiol, Minneapolis, MN 55455 USA Univ Minnesota, Biol Proc Technol Inst, Minneapolis, MN 55455 USA Univ Minnesota Minneapolis MN USA 55455 l Inst, Minneapolis, MN 55455 USA
Titolo Testata:
GENE
fascicolo: 1, volume: 245, anno: 2000,
pagine: 203 - 211
SICI:
0378-1119(20000307)245:1<203:GAOTPS>2.0.ZU;2-T
Fonte:
ISI
Lingua:
ENG
Soggetto:
STREPTOMYCES-VENEZUELAE; BIOSYNTHESIS; SEQUENCE; IDENTIFICATION; DOMAINS;
Keywords:
antibiotics; gene cluster; ketolide; modular PKS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
31
Recensione:
Indirizzi per estratti:
Indirizzo: Sherman, DH Univ Minnesota, Dept Microbiol, Minneapolis, MN 55455 USA UnivMinnesota Minneapolis MN USA 55455 eapolis, MN 55455 USA
Citazione:
Y.Q. Xue et al., "Genetic architecture of the polyketide synthases for methymycin and pikromycin series macrolides", GENE, 245(1), 2000, pp. 203-211

Abstract

The methymycin and pikromycin series of antibiotics are structurally related macrolides produced by several Streptomyces species, including Streptomyces venezuelae ATCC 15439, which produces both 12-membered ring macrolides methymycin, neomethymycin, and 14-membered ring macrolides pikromycin and narbomycin. Cloning and sequencing of the biosynthetic gene clusters for these macrolides from three selected Streptomyces strains revealed a common genetic architecture of their polyketide syntheses (PKSs). Unlike PKS clusters of other 14-membered ring macrolides such as erythromycin and oleandomycin, each of the pikromycin series producers harbors a six module PKS cluster, in which modules 5 and 6 are encoded on two separate proteins instead of one bimodular protein, as well as a thioesterase II gene immediately downstream of the main PKS gene. The results shed new light on the evolution of modular PKSs and provide further evidence on the regulation of methymycin and pikromycin production in S. venezuelae ATCC 15439. (C) 2000 Elsevier Science B.V. All rights reserved.

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Documento generato il 03/12/20 alle ore 05:07:44