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Titolo:
Anti-inflammatory properties of ebselen in a model of sephadex-induced lung inflammation
Autore:
Belvisi, MG; Haddad, EB; Battram, C; Birrell, M; Foster, M; Webber, S;
Indirizzi:
Aventis Pharma, Dept Pharmacol, Dagenham Res Ctr, Dagenham RM10 7XS, Essex, England Aventis Pharma Dagenham Essex England RM10 7XS m RM10 7XS, Essex, England
Titolo Testata:
EUROPEAN RESPIRATORY JOURNAL
fascicolo: 3, volume: 15, anno: 2000,
pagine: 579 - 581
SICI:
0903-1936(200003)15:3<579:APOEIA>2.0.ZU;2-5
Fonte:
ISI
Lingua:
ENG
Soggetto:
TUMOR-NECROSIS-FACTOR; FACTOR-ALPHA; ENDOTHELIN; COMPOUND;
Keywords:
airway inflammation; lung oedema; sephadex tumour necrosis factor-alpha;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
14
Recensione:
Indirizzi per estratti:
Indirizzo: Belvisi, MG Aventis Pharma, Dept Pharmacol, Dagenham Res Ctr, Rainham Rd S, Dagenham RM10 7XS, Essex, England Aventis Pharma Rainham Rd S Dagenham Essex England RM10 7XS nd
Citazione:
M.G. Belvisi et al., "Anti-inflammatory properties of ebselen in a model of sephadex-induced lung inflammation", EUR RESP J, 15(3), 2000, pp. 579-581

Abstract

Ebselen (2-phenyl-1,2-benzisoselenazol-3(2H)-one), is a seleno-organic compound which protects tissues against oxidative stress. Furthermore, recent data has suggested that this compound possesses a range of anti-inflammatory properties. In this study the authors have investigated the effects of ebselen on Sephadex-induced lung oedema and bronchoalveolar lavage (BAL) tumour necrosis factor (TNF)-alpha and endothelin(ET)-1 levels in rats. Sephadex administration induced lung oedema which was accompanied by an increase in BAL TNF-alpha and ET-1 levels. Ebselen administration (1-30 mg.kg(-1), ip, at 0, 4 and 12 h post Sephadex) significantly inhibited lung oedema (dose that produced 50% of the maximum inhibition of lung oedema 4.6 mg.k(-1)) and BAL TNF-alpha Levels in a dose-related manner with no effect on ET-1 levels. These data suggest that ebselen may be a useful therapy in lung pathologies in which bronchiolar inflammation is a feature.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/11/20 alle ore 18:25:04