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Titolo:
NOS inhibition during postnatal development leads to increased ipsilateralretinocollicular and retinogeniculate projections in rats
Autore:
Vercelli, A; Garbossa, D; Biasiol, S; Repici, M; Jhaveri, S;
Indirizzi:
Dept Anat Pharmacol & Forens Med, I-10126 Turin, Italy Dept Anat Pharmacol& Forens Med Turin Italy I-10126 -10126 Turin, Italy MIT, Dept Brain & Cognit Sci, Cambridge, MA 02139 USA MIT Cambridge MA USA 02139 pt Brain & Cognit Sci, Cambridge, MA 02139 USA
Titolo Testata:
EUROPEAN JOURNAL OF NEUROSCIENCE
fascicolo: 2, volume: 12, anno: 2000,
pagine: 473 - 490
SICI:
0953-816X(200002)12:2<473:NIDPDL>2.0.ZU;2-Y
Fonte:
ISI
Lingua:
ENG
Soggetto:
NITRIC-OXIDE SYNTHASE; LATERAL GENICULATE-NUCLEUS; CENTRAL-NERVOUS-SYSTEM; NADPH-DIAPHORASE; SUPERIOR COLLICULUS; SYNAPTIC ORGANIZATION; VISUAL-SYSTEM; RETINOTECTAL PROJECTION; RETINOFUGAL PATHWAYS; TRANSIENT EXPRESSION;
Keywords:
cholera toxin; L-nitro-arginine; lateral geniculate nucleus; nitric oxide; retinal axons; superior colliculus;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
81
Recensione:
Indirizzi per estratti:
Indirizzo: Vercelli, A Dept Anat Pharmacol & Forens Med, I-10126 Turin, Italy Dept Anat Pharmacol & Forens Med Turin Italy I-10126 , Italy
Citazione:
A. Vercelli et al., "NOS inhibition during postnatal development leads to increased ipsilateralretinocollicular and retinogeniculate projections in rats", EUR J NEURO, 12(2), 2000, pp. 473-490

Abstract

Synthesis of nitric oxide (NO) occurs downstream from activation of N-methyl-d-aspartate (NMDA) receptors; NO reportedly acts as a retrograde messenger, influencing the refinement and stabilization of coactive afferent terminals. Cells and neuropil in the rat superior colliculus (SC) and lateral geniculate body (LGB) show intense, developmentally regulated activity for NOsynthase (NOS). To study the role of NO in the development of retinogeniculate and retinotectal axon arbors, we examined primary visual projections of rats that had received intraperitoneal injections of N-omega-nitro-l-arginine (L-NoArg, an NOS inhibitor) on postnatal day 0, and daily thereafter for 4-6 weeks. Treated rats showed significant alterations in ipsilateral retinotectal projections, in the mediolateral and anteroposterior axes; therewas an increase in the density of fibres entering the SC, in branch length, and in the numbers of boutons on retinotectal arbors in the treated group. Ipsilaterally projecting retinal axons also showed an increase in densityand distribution in the dorsal nucleus of the LGB. If animals were allowedto survive for several months after stopping treatment, similar changes were also noted, but these were much less striking. Our results support the hypothesis that, in the mammalian visual system, NO released from target neurons in the SC and LGB serves as a retrograde signal which feeds back on retinal afferents, influencing their growth. The effects of NOS inhibition are partially reversed after treatment is stopped, indicating that lack of NOsynthesis delays the maturation of retinofugal connections, and also that NO plays a constitutive role in their development.

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Documento generato il 25/11/20 alle ore 17:36:48