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Titolo:
Hepatic arterial chemoembolization with streptozotocin in patients with metastatic digestive endocrine tumours
Autore:
Dominguez, S; Denys, A; Madeira, I; Hammel, P; Vilgrain, V; Menu, Y; Bernades, P; Ruszniewski, P;
Indirizzi:
Hop Beaujon, Serv Gastroenterol, Federat Hepatogastroenterol, F-92118 Clichy, France Hop Beaujon Clichy France F-92118 ogastroenterol, F-92118 Clichy, France
Titolo Testata:
EUROPEAN JOURNAL OF GASTROENTEROLOGY & HEPATOLOGY
fascicolo: 2, volume: 12, anno: 2000,
pagine: 151 - 157
SICI:
0954-691X(200002)12:2<151:HACWSI>2.0.ZU;2-M
Fonte:
ISI
Lingua:
ENG
Soggetto:
ISLET-CELL-CARCINOMA; TRANSCATHETER OILY CHEMOEMBOLIZATION; NEUROENDOCRINE TUMORS; INTRAARTERIAL CHEMOTHERAPY; HEPATOCELLULAR-CARCINOMA; OCTREOTIDE ACETATE; LIVER METASTASIS; EMBOLIZATION; THERAPY; FLUOROURACIL;
Keywords:
carcinoid tumors; chemoembolization; digestive endocrine tumours; islet cell carcinomas; liver metastases; streptozotocin;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
41
Recensione:
Indirizzi per estratti:
Indirizzo: Ruszniewski, P Hop Beaujon, Serv Gastroenterol, Federat Hepatogastroenterol, 100 Blvd GenLeclerc, F-92118 Clichy, France Hop Beaujon 100 Blvd Gen Leclerc Clichy France F-92118 nce
Citazione:
S. Dominguez et al., "Hepatic arterial chemoembolization with streptozotocin in patients with metastatic digestive endocrine tumours", EUR J GASTR, 12(2), 2000, pp. 151-157

Abstract

Background Hepatic arterial chemoembolization (CE) with anthracyclines is an effective treatment for progressive liver metastases of digestive endocrine tumours, Streptozotocin (STZ) is widely used for systemic chemotherapy,but its efficacy by the hepatic arterial route has not been evaluated. Patients and methods Fifteen consecutive patients, mean age 57.8 years, were prospectively included between July 1993 and January 1997. All patients had progressive liver metastases from either a carcinoid tumour (eight patients) or an islet cell carcinoma (ICC) (seven patients) that had increased in size (greater than or equal to 25%) before CE, Five patients had the carcinoid syndrome, STZ was administered, as an emulsion with iodized oil, into the hepatic artery before embolization with gelatin sponge particles. Twoto six procedures (median, 3) were performed in 12 patients (one in three patients). Changes in the size of the liver metastases were evaluated by CTscan or MRI according to WHO criteria, The median follow-up was 15 months (1 - 50),Results An objective response was achieved in 8/15 patients (53%; median duration of 10.5 months) whatever the primary tumour (carcinoid or ICC). Thecarcinoid syndrome disappeared in 3/5 patients for 10, 11 and 17 months, respectively. CE effectively controlled hypoglycaemic attacks (decrease of >50%) in the patient with insulinoma. The biological response was complete in four patients for a median duration of 7 months. CE induced minor side effects, namely nausea, fever and abdominal pain. Acute and reversible tubular necrosis due to CE was observed in one patient who had previously undergone a nephrectomy. Conclusion Hepatic arterial chemoembolization with STZ is an effective treatment for patients with liver metastases caused by digestive endocrine tumours, Eur J Gastroenterol Hepatol 12:151-157 (C) 2000 Lippincott Williams &Wilkins.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 28/09/20 alle ore 18:42:46