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Titolo:
Distinct patterns of cytokine regulation in discrete clinical forms of Plasmodium falciparum malaria
Autore:
Akanmori, BD; Kurtzhals, JAL; Goka, BQ; Adabayeri, V; Ofori, MF; Nkrumah, FK; Behr, C; Hviid, L;
Indirizzi:
Univ Ghana, Noguchi Mem Inst Med Res, Immunol Unit, Legon, Ghana Univ Ghana Legon Ghana chi Mem Inst Med Res, Immunol Unit, Legon, Ghana Univ Ghana, Sch Med, Dept Child Hlth, Accra, Ghana Univ Ghana Accra Ghana iv Ghana, Sch Med, Dept Child Hlth, Accra, Ghana Copenhagen Univ Hosp, Rigshosp, Dept Infect Dis, Ctr Med Parasitol, Copenhagen, Denmark Copenhagen Univ Hosp Copenhagen Denmark Parasitol, Copenhagen, Denmark Univ Copenhagen, Rigshosp, Inst Med Microbiol & Immunol, Copenhagen, Denmark Univ Copenhagen Copenhagen Denmark obiol & Immunol, Copenhagen, Denmark Inst Pasteur, Unite Immunol Mol Parasites, CNRS, URA 1960, Paris, France Inst Pasteur Paris France Mol Parasites, CNRS, URA 1960, Paris, France
Titolo Testata:
EUROPEAN CYTOKINE NETWORK
fascicolo: 1, volume: 11, anno: 2000,
pagine: 113 - 118
SICI:
1148-5493(200003)11:1<113:DPOCRI>2.0.ZU;2-S
Fonte:
ISI
Lingua:
ENG
Soggetto:
TUMOR-NECROSIS-FACTOR; CEREBRAL MALARIA; FACTOR-ALPHA; RECEPTORS CORRELATE; DISEASE SEVERITY; PLASMA-LEVELS; CELL-LINES; TNF; ANEMIA; CHILDREN;
Keywords:
TNF; TNF-R1; TNF-R2; cerebral; malaria; anaemia;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
29
Recensione:
Indirizzi per estratti:
Indirizzo: Akanmori, BD Univ Ghana, Noguchi Mem Inst Med Res, Immunol Unit, Box 25, Legon, Ghana Univ Ghana Box 25 Legon Ghana ol Unit, Box 25, Legon, Ghana
Citazione:
B.D. Akanmori et al., "Distinct patterns of cytokine regulation in discrete clinical forms of Plasmodium falciparum malaria", EUR CYTOKIN, 11(1), 2000, pp. 113-118

Abstract

The pathogenesis of two of the most severe complications of Plasmodium falciparum malaria, cerebral malaria (CM) and severe malarial anaemia (SA) both appear to involve dysregulation of the immune system. We have measured plasma levels of TNF and its two receptors in Ghanaian children with strictlydefined cerebral malaria (CM), severe malarial anaemia (SA), or uncomplicated malaria (UM) in two independent studies in an area of seasonal, hyperendemic transmission of P. falciparum. Levels of TNF, soluble TNF receptor 1 (sTNF-R1) and 2 (sTNF-R2) were found to be significantly higher in CM than in the other clinical categories of P. falciparum malaria patients. Levels of both receptors depended on clinical category, whereas only sTNF-R1 levels were significantly dependent on parasitemia, Detailed analysis of the interrelationship between these variables resolved this pattern further, and identified marked differences between the patient categories. While levels of TNF, sTNF-R1 and sTNF-R2 correlated with parasitemia in UM, this was not the case in CM and SA, Rather, there was a tendency towards high levels of TNF and its receptors in CM and low levels in SA without significant correlation to parasitemia in either category. This, and the fact that malaria-induced increases in plasma levels of IL-10 are much lower in SA compared to CM, suggest that distinct forms of dysregulation of the immune response to infection contribute to the pathogenesis of CM and SA.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 13/07/20 alle ore 20:23:51