Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Superoxide dismutase in human adrenal and its disorders: A correlation with development and neoplastic changes
Autore:
Sasano, H; Mizorogi, A; Sato, M; Nakazumi, H; Suzuki, T;
Indirizzi:
Tohoku Univ, Sch Med, Dept Pathol, Aoba Ku, Sendai, Miyagi 9808575, Japan Tohoku Univ Sendai Miyagi Japan 9808575 Ku, Sendai, Miyagi 9808575, Japan
Titolo Testata:
ENDOCRINE PATHOLOGY
fascicolo: 4, volume: 10, anno: 1999,
pagine: 325 - 333
SICI:
1046-3976(199924)10:4<325:SDIHAA>2.0.ZU;2-I
Fonte:
ISI
Lingua:
ENG
Soggetto:
LINKED-IMMUNOSORBENT-ASSAY; MESSENGER-RIBONUCLEIC-ACID; RAT CORPUS-LUTEUM; MONOCLONAL-ANTIBODY; BREAST-CARCINOMA; FREE-RADICALS; COPPER; INDUCTION; CORTEX; CANCER;
Keywords:
adrenal; superoxide dismutase; neoplasms; human; immunohistochemistry;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
36
Recensione:
Indirizzi per estratti:
Indirizzo: Sasano, H Tohoku Univ, Sch Med, Dept Pathol, Aoba Ku, 2-1 Seiryou Machi, Sendai, Miyagi 9808575, Japan Tohoku Univ 2-1 Seiryou Machi Sendai Miyagi Japan 9808575 Japan
Citazione:
H. Sasano et al., "Superoxide dismutase in human adrenal and its disorders: A correlation with development and neoplastic changes", ENDOCR PATH, 10(4), 1999, pp. 325-333

Abstract

In adrenal glands, oxidative free radicals are synthesized in the course of hormonal production, and enzyme superoxide dismutase (SOD) is considered to scavenge these harmful superoxide radicals and, subsequently, to protectthe cells. We studied immunohistochemical localization of Mn (manganese)-SOD and Cu,Zn (copper-zinc)-SOD in human adrenal and its disorders from fetus to adult obtained from autopsy or surgery in order to examine the possible biological significance of these two enzymes. In fetal adrenal (n = 4), Cu,Zn-SOD and Mn-SOD were detected only in the fetal cortex. In adrenal glands from children (n = 21) to adults (n = 15), Mn-SOD immunoreactivity was exclusively detected in adrenal medulla, whereas Cu,Zn-SOD immunoreactivity was present only in adrenocortical parenchymal cells, weakly in the zona glomerulosa, and markedly in the zona reticularis. There were no differences in relative immunointensity and/or patterns of immunolocalization of these two SODs among different age groups. Both Cu,Zn-SOD and MnSOD immunoreactivity were detected in compact tumor cells of adrenocortical adenoma (n = 16). Marked immunoreactivity of both Cu,Zn-SOD and Mn-SOD was detected in adrenocortical carcinoma (n = 11) and pheochromocytoma (n = 5). These results indicate that Cu,Zn-SOD and Mu-SOD may play different roles as a scavenger or antioxidants in normal human adrenal glands, i.e., Cu,Zn-SOD as a scavenger of toxic superoxide radicals generated during steroidogenesis and Mn-SODduring catecholamine production. Cu,Zn-SOD and Mn-SOD immunoreactivities detected in adrenal neoplasms are also considered to represent altered expression of these enzymes associated with neoplastic transformation, as reported in other human malignancies.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 23/09/20 alle ore 22:14:51