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Titolo:
Novel chicken CXC and CC chemokines
Autore:
Sick, C; Schneider, K; Staeheli, P; Weining, KC;
Indirizzi:
Univ Freiburg, Dept Virol, Inst Med Mikrobiol & Hyg, Abt Virol, D-79008 Freiburg, Germany Univ Freiburg Freiburg Germany D-79008 Virol, D-79008 Freiburg, Germany
Titolo Testata:
CYTOKINE
fascicolo: 3, volume: 12, anno: 2000,
pagine: 181 - 186
SICI:
1043-4666(200003)12:3<181:NCCACC>2.0.ZU;2-0
Fonte:
ISI
Lingua:
ENG
Soggetto:
GRANULOCYTE CHEMOTACTIC PROTEIN-2; AVIAN LEUKEMIA VIRUSES; MOLECULAR-CLONING; PLATELET PROTEIN; INTERFERON-GAMMA; IN-VIVO; EXPRESSION; GENE; FAMILY; CELLS;
Keywords:
chicken macrophages; CC chemokine; CXC chemokine; LPS induction; representational difference analysis;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
47
Recensione:
Indirizzi per estratti:
Indirizzo: Staeheli, P Univ Freiburg, Dept Virol, Inst Med Mikrobiol & Hyg, Abt Virol, Hermann Herder Str 11, D-79008 Freiburg, Germany Univ Freiburg Hermann Herder Str 11 Freiburg Germany D-79008
Citazione:
C. Sick et al., "Novel chicken CXC and CC chemokines", CYTOKINE, 12(3), 2000, pp. 181-186

Abstract

Upon stimulation with lipopolysaccharide (LPS) the chicken macrophage cellline HD-11 secretes factors with cytokine activity. To characterize these molecules, representational difference analysis with RNA of LPS-induced anduninduced HD-11 cells was performed, Two cDNA clones were isolated that code for polypeptides with structural features of chemokines. cDNA K60 codes for a novel CXC chemokine of 104 residues including a putative signal peptide of 20 amino acids at the N-terminus, It is 67% identical to the previously cloned chicken chemokine 9E3/CEF4. K60 exhibits a similar degree of sequence identity to human interleukin 8 and other related CXC chemokines (about 50%), rendering straight-forward predictions of its biological propertiesdifficult. cDNA K203 codes for a novel CC chemokine of 89 amino acids including a putative N-terminal signal peptide of 21 residues, It is 43% identical to a previously characterized chicken protein with homology to mammalian macrophage inflammatory protein 1 beta (MIP-1 beta), K203 exhibits about 50% sequence identity to human MIP-1 beta and other related CC chemokines. (C) 2000 Academic Press.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 22/01/20 alle ore 06:52:00