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Titolo:
Changes in baroreceptor sensitivity for heart rate during normotensive pregnancy and the puerperium
Autore:
Blake, MJ; Martin, A; Manktelow, BN; Armstrong, C; Halligan, AW; Panerai, RB; Potter, JF;
Indirizzi:
Univ Leicester, Dept Med Elderly, Leicester, Leics, England Univ Leicester Leicester Leics England lderly, Leicester, Leics, England Univ Leicester, Dept Obstet & Gynaecol, Leicester, Leics, England Univ Leicester Leicester Leics England naecol, Leicester, Leics, England Univ Leicester, Dept Med Phys, Leicester, Leics, England Univ Leicester Leicester Leics England d Phys, Leicester, Leics, England
Titolo Testata:
CLINICAL SCIENCE
fascicolo: 3, volume: 98, anno: 2000,
pagine: 259 - 268
SICI:
0143-5221(200003)98:3<259:CIBSFH>2.0.ZU;2-J
Fonte:
ISI
Lingua:
ENG
Soggetto:
BLOOD-PRESSURE MEASUREMENT; POWER SPECTRAL-ANALYSIS; ANGIOTENSIN-II; INDUCED HYPERTENSION; BAROREFLEX CONTROL; ARTERIAL-PRESSURE; NEURAL REGULATION; PLASMA; WOMEN; VARIABILITIES;
Keywords:
baroreceptor sensitivity; blood pressure; pregnancy;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
52
Recensione:
Indirizzi per estratti:
Indirizzo: Blake, MJ Univ Leicester, Dept Med Elderly, Leicester, Leics, England UnivLeicester Leicester Leics England icester, Leics, England
Citazione:
M.J. Blake et al., "Changes in baroreceptor sensitivity for heart rate during normotensive pregnancy and the puerperium", CLIN SCI, 98(3), 2000, pp. 259-268

Abstract

Normal pregnancy is associated with marked changes in cardiovascular haemodynamics, which in part may be due to changes in autonomic control mechanisms. Baroreflex sensitivity for heart rate (BRS) was calculated in the supine and standing positions using power spectral analysis of pulse interval (PI) and systolic blood pressure (SBP) in 16 normotensive pregnant women and 10 normotensive non-pregnant controls. The pregnant women were studied on three occasions during their pregnancy (early, mid- and late gestation) and once during the puerperium. Supine total SEP variability increased between early and late pregnancy by 79% [95% confidence intervals (CI) 30%, 145%; P< 0.001], and supine high-frequency PI variability decreased by 75% (CI 51%, 88%; P < 0.001). Supine BRS fell by 50% (P < 0.001), with values returning to early-pregnancy levels in the puerperium, which were similar to thoserecorded in the control group. Standing SEP variability and BRS values were unchanged during pregnancy and post partum. The low/high frequency ratio of PI variability, taken as a surrogate measure of sympathovagal balance. increased by 137% (CI 42%, 296%; P < 0.01) in the supine but not the standing position from early to late pregnancy. This was due to a decrease in high-frequency variability rather than to an increase in low-frequency variability, suggesting that these changes may have been due to vagal withdrawal rather than increased sympathetic activity. Normotensive pregnancy is associated with a marked decrease in supine BRS, although the exact mechanisms forthese changes remain unclear. Further studies are required to define whether changes in BRS and sympathovagal tone in early pregnancy can be used to predict the onset of pregnancy-induced hypertension.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 30/11/20 alle ore 03:28:55