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Titolo:
Complete correction of renal anemia by recombinant human erythropoietin
Autore:
Ludat, K; Paulitschke, M; Riedel, E; Hampl, H;
Indirizzi:
Humboldt Univ, Med Klin, Schwerpunkt Nephrol, Dept Nephrol & Intens Care Med, D-13353 Berlin, Germany Humboldt Univ Berlin Germany D-13353 s Care Med, D-13353 Berlin, Germany Cell Lining GmbH, Berlin, Germany Cell Lining GmbH Berlin GermanyCell Lining GmbH, Berlin, Germany Free Univ Berlin, Inst Biochem, D-1000 Berlin, Germany Free Univ Berlin Berlin Germany D-1000 t Biochem, D-1000 Berlin, Germany
Titolo Testata:
CLINICAL NEPHROLOGY
, volume: 53, anno: 2000, supplemento:, 1
pagine: S42 - S49
SICI:
0301-0430(200002)53:<S42:CCORAB>2.0.ZU;2-8
Fonte:
ISI
Lingua:
ENG
Soggetto:
HEMODIALYSIS-PATIENTS; DIALYSIS PATIENTS; HEMODYNAMIC-CHANGES; THERAPY; DISEASE; IMPROVES; RHUEPO; HYPERTENSION; HEMATOCRIT; HEMOGLOBIN;
Keywords:
hemodialysis; ultra-filtration; hemoconcentration; blood rheology; whole blood viscosity; plasma viscosity; red blood cell aggregation; red blood cell deformability;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
50
Recensione:
Indirizzi per estratti:
Indirizzo: Ludat, K Humboldt Univ, Med Klin, Schwerpunkt Nephrol, Dept Nephrol & Intens Care Med, Campus Virchow Klinikum,Augustenburger Pl 1, D-13353 Berlin, Germany Humboldt Univ Campus Virchow Klinikum,Augustenburger Pl 1 Berlin Germany D-13353
Citazione:
K. Ludat et al., "Complete correction of renal anemia by recombinant human erythropoietin", CLIN NEPHR, 53, 2000, pp. S42-S49

Abstract

The target-hematocrit (Hct) For the correction of renal anemia by recombinant human erythropoeitin (rhEPO) therapy is discussed controversially. A normalization of the Hct that: could lead to a further improvement of the patients status, is often rejected, because of possible side effects as a result of an increase in blood viscosity. Hemodialysis (HD) induces an acute hemoconcentration due to ultrafiltration. that might influence these risk factors negatively and therefore conflict with the normalization of Hct. The aim of this study was to investigate the changes in rheological and biochemical parameters in chronic HD patients with a normal initial Hct before hemodialysis, Results in 39 patients are given as mean +/- SD before/after HD: Hct 0.42 +/- 0.05/0.45 +/- 0.05 (p < 0.001), hemoglobin (g/dI) 13.3 +/- 1.0/14.4 +/- 1.3 (p < 0.001), MCV (fl) 99.3 +/- 5.7/99.1 +/- 5.5, MCHC (mM/l) 19.9 +/- 0.6/20.1 +/- 0.6 (p < 0.01), red blood cell (RBC) elongation (%) 60.97 +/- 3.67/60.99 +/- 3.75, RBC aggregation index AI(0) 0.52 +/- 0.12/0.50 +/- 0.12, AI(4) 0.52 +/- 0.14/0.51 +/- 0.12, plasma viscosity 1.74 +/- 0.14/1.92 +/- 0.20 (p < 0.001), whole blood viscosity (WBV), eta(abs.100)(mPas) 5.91 +/- 0.78/6.80 +/- 1.2 (p < 0.001), eta(abs.0.01)(mPas) 75.81 +/- 35.48/167.656 +/- 98.656 (p < 0.05), ultrafiltration (FM) 2.1 +/- 1.1. The biochemical parameters protein, albumin, IgG, IgA, IgM, cholesterol, transferrin and fibrinogen are significantly increased after HD. The hemoconcentration during HD is associated with a significant increase in WBV, mainly associated with the increase in Hct (r = 0.83), but not exceeding the; normal range compared to healthy controls. The Increase in plasma viscosity is correlated mainly with an increase in protein (r = 0.80), albumin (r = 0.74), and fibrinogen (r = 0.54). No significant changes in RBC aggregation and deformability were observed during the I-FD session. In conclusion, from the rheological point of view it is unlikely that the normalization of the Hct will contribute to an increased risk in access thrombosis or thromboembolic events in IID patients.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 15/07/20 alle ore 21:26:54