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Titolo:
Interleukin-6 release by cultured peripheral blood mononuclear cells inversely correlates with height velocity, bone age, insulin-like growth factor-I, and insulin-like growth factor binding protein-3 serum levels in children with perinatal HIV-1 infection
Autore:
de Martino, M; Galli, L; Chiarelli, F; Verrotti, A; Rossi, ME; Bindi, G; Galluzzi, F; Salti, R; Vierucci, A;
Indirizzi:
Univ Florence, Dept Pediat, I-50132 Florence, Italy Univ Florence Florence Italy I-50132 ept Pediat, I-50132 Florence, Italy Univ Chieti, Dept Med, Div Pediat, Chieti, Italy Univ Chieti Chieti Italy iv Chieti, Dept Med, Div Pediat, Chieti, Italy
Titolo Testata:
CLINICAL IMMUNOLOGY
fascicolo: 3, volume: 94, anno: 2000,
pagine: 212 - 218
SICI:
1521-6616(200003)94:3<212:IRBCPB>2.0.ZU;2-E
Fonte:
ISI
Lingua:
ENG
Soggetto:
IMMUNODEFICIENCY-VIRUS TYPE-1; RECEPTOR ANTAGONIST; SURVIVING LONGER; CELIAC-DISEASE; IGF-I; HORMONE; IMPAIRMENT; CYTOKINES;
Keywords:
IL-6; IGF-I; IGFBP-3; linear growth; HIV-1; children;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
40
Recensione:
Indirizzi per estratti:
Indirizzo: de Martino, M Univ Florence, Dept Pediat, Via Luca Giordano 13, I-50132 Florence, Italy Univ Florence Via Luca Giordano 13 Florence Italy I-50132 y
Citazione:
M. de Martino et al., "Interleukin-6 release by cultured peripheral blood mononuclear cells inversely correlates with height velocity, bone age, insulin-like growth factor-I, and insulin-like growth factor binding protein-3 serum levels in children with perinatal HIV-1 infection", CLIN IMMUNO, 94(3), 2000, pp. 212-218

Abstract

Spontaneous and phytohemagglutinin (PHA)-stimulated interleukin (IL)-6 release by cultured peripheral blood mononuclear cells was related to height velocity, bone age, insulin-like growth factor-I (IGF-I), and IGF binding protein-3 (IGFBP-3) serum level standard deviation scores (SDS) of 32 children [aged 91 (median; range 13-151) months] with human immunodeficiency virus-type 1 (HIV-1) perinatal infection and severe disease. Spontaneous and PHA-stimulated IL-6 release inversely correlated with height velocity, bone age, IGF-I, and IGFBP-3 SDS, Ten children with height velocity SDS less than or equal to -2, compared to 22 children with height velocity SDS > -2, showed higher spontaneous and PHA-stimulated IL-6 release and lower IGF-I and IGFBP-3 SDS (irrespective of CD4-positive T-lymphocyte counts, viral load, liver disease, or nutrition status). IL-6 overproduction may be a mechanism of IGF-I and IGFBP-3 down-regulation and impaired linear growth in childrenwith perinatal HIV-1 infection. Growth-promoting strategies, including targeted anticytokine treatments, could be devised for such children. (C) 2000Academic Press.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 08/08/20 alle ore 08:59:34