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Titolo:
Major racial differences in coronary constrictor response between Japaneseand Caucasians with recent myocardial infarction
Autore:
Pristipino, C; Beltrame, JF; Finocchiaro, ML; Hattori, R; Fujita, M; Mongiardo, R; Cianflone, D; Sanna, T; Sasayama, S; Maseri, A;
Indirizzi:
Univ Cattolica Sacro Cuore, Ist Cardiol, I-00168 Rome, Italy Univ Cattolica Sacro Cuore Rome Italy I-00168 rdiol, I-00168 Rome, Italy Univ Adelaide, Adelaide, SA, Australia Univ Adelaide Adelaide SA Australia iv Adelaide, Adelaide, SA, Australia Kyoto Univ, Kyoto, Japan Kyoto Univ Kyoto JapanKyoto Univ, Kyoto, Japan
Titolo Testata:
CIRCULATION
fascicolo: 10, volume: 101, anno: 2000,
pagine: 1102 - 1108
SICI:
0009-7322(20000314)101:10<1102:MRDICC>2.0.ZU;2-B
Fonte:
ISI
Lingua:
ENG
Soggetto:
ARTERY LESIONS; ACETYLCHOLINE; DISEASE; SPASM; MECHANISMS;
Keywords:
vasoconstriction; vasospasm; vasodilation; myocardial infarction; acetylcholine;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
17
Recensione:
Indirizzi per estratti:
Indirizzo: Pristipino, C Univ Cattolica Sacro Cuore, Ist Cardiol, Lgo Agostino Gemelli 1, I-00168 Rome, Italy Univ Cattolica Sacro Cuore Lgo Agostino Gemelli 1 Rome Italy I-00168
Citazione:
C. Pristipino et al., "Major racial differences in coronary constrictor response between Japaneseand Caucasians with recent myocardial infarction", CIRCULATION, 101(10), 2000, pp. 1102-1108

Abstract

Background-Enhanced coronary vasomotion may contribute to acute coronary occlusion during the acute phase of myocardial infarction (AMI). Japanese have a higher incidence of variant angina than Caucasian patients, but racialdifferences in vasomotor reactivity early after AMI are controversial. Methods and Results-The same team studied 15 Japanese and 19 Caucasian patients within 14 days of AMI by acetylcholine injection into non-infarct-related (NIRA) and infarct-related (IRA) coronary arteries followed by nitroglycerin. Incidence of vasodilation, vasoconstriction, spasm, and basal tone were assessed in proximal, middle, and distal segments after each drug bolus by quantitative angiography, Japanese patients had much lower cholesterollevels than Caucasians (183 +/- 59 versus 247 +/- 53 mg/dL, P<0.006) but showed a lower incidence of vasodilation (2% versus 9% of coronary segments)and a greater incidence of spasm after acetylcholine (47% versus 15% of arteries, P<0.00001). Incidence of spasm was higher in IRAs than in NIRAs in both populations (67% versus 39% and 23% versus 11%, respectively). Multivessel spasm was more common (64% versus 17%, P<0.02) and vasoconstriction ofnonspastic segments was greater in Japanese patients (-23.4 +/- 14.9% versus -20.1 +/- 15.7%, P<0.02) in the presence of similar average basal coronary tone with respect to post-nitroglycerin dilation and of nonsignificant differences of coronary atherosclerotic score. Conclusions-Soon after AMI, Japanese patients exhibited a 3-fold-greater incidence of spasm and greater vasoconstriction of nonspastic segments afteracetylcholine than Caucasians. The causes of such differences warrant further investigation because they may have relevant pathophysiological and therapeutic implications.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 03/04/20 alle ore 09:49:37