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Titolo:
Expression and function of PPAR gamma in rat and human vascular smooth muscle cells
Autore:
Law, RE; Goetze, S; Xi, XP; Jackson, S; Kawano, Y; Demer, L; Fishbein, MC; Meehan, WP; Hsueh, WA;
Indirizzi:
Univ Calif Los Angeles, Sch Med, Dept Med, Los Angeles, CA 90095 USA Univ Calif Los Angeles Los Angeles CA USA 90095 Los Angeles, CA 90095 USA Univ Calif Los Angeles, Sch Med, Div Endocrinol Diabet & Hypertens, Los Angeles, CA 90095 USA Univ Calif Los Angeles Los Angeles CA USA 90095 Los Angeles, CA 90095 USA Univ Calif Los Angeles, Sch Med, Div Cardiol, Los Angeles, CA 90095 USA Univ Calif Los Angeles Los Angeles CA USA 90095 Los Angeles, CA 90095 USA Univ Calif Los Angeles, Sch Med, Dept Pathol & Lab Med, Los Angeles, CA 90095 USA Univ Calif Los Angeles Los Angeles CA USA 90095 Los Angeles, CA 90095 USA
Titolo Testata:
CIRCULATION
fascicolo: 11, volume: 101, anno: 2000,
pagine: 1311 - 1318
SICI:
0009-7322(20000321)101:11<1311:EAFOPG>2.0.ZU;2-I
Fonte:
ISI
Lingua:
ENG
Soggetto:
ACTIVATED RECEPTOR-GAMMA; GENE-EXPRESSION; ADIPOCYTE DIFFERENTIATION; DIABETES-MELLITUS; OXIDIZED LDL; PROLIFERATOR; TROGLITAZONE; ATHEROSCLEROSIS; MACROPHAGES; LIGAND;
Keywords:
atherosclerosis; restenosis; growth substances; migration; thiazolidinediones;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
33
Recensione:
Indirizzi per estratti:
Indirizzo: Law, RE Univ Calif Los Angeles, Sch Med, Dept Med, Warren Hall,2nd Floor,Suite 24-130,900 Vet Ave, Los Angeles, CA 90095 USA Univ Calif Los Angeles Warren Hall,2nd Floor,Suite 24-130,900 Vet Ave Los Angeles CA USA 90095
Citazione:
R.E. Law et al., "Expression and function of PPAR gamma in rat and human vascular smooth muscle cells", CIRCULATION, 101(11), 2000, pp. 1311-1318

Abstract

Background-Peroxisome proliferator-activated receptor-gamma (PPAR gamma) is activated by fatty acids, eicosanoids, and insulin-sensitizing thiazolidinediones (TZDs). The TZD troglitazone (TRO) inhibits vascular smooth musclecell (VSMC) proliferation and migration in vitro and in postinjury intimalhyperplasia. Methods and Results-Rat and human VSMCs express mRNA and nuclear receptorsfor PPAR gamma 1. Three PPAR gamma ligands, the TZDs TRO and rosiglitazoneand the prostanoid 15-deoxy-Delta(12,14)-prostaglandin J2 (15d-PGJ2), all inhibited VSMC proliferation and migration. PPAR gamma is upregulated in rat neointima at 7 days and 14 days after balloon injury and is also present in early human atheroma and precursor lesions. Conclusions-Pharmacological activation of PPAR gamma expressed in VSMCs inhibits their proliferation and migration, potentially limiting restenosis and atherosclerosis. These receptors are upregulated during vascular injury.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 28/03/20 alle ore 12:12:13