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Titolo:
Orbital and medial prefrontal cortex and psychostimulant abuse: Studies inanimal models
Autore:
Porrino, LJ; Lyons, D;
Indirizzi:
Wake Forest Univ, Sch Med, Dept Physiol & Pharmacol, Ctr Neurobiol Invest Abused Drugs, Winston Salem, NC 27157 USA Wake Forest Univ Winston Salem NC USA 27157 , Winston Salem, NC 27157 USA
Titolo Testata:
CEREBRAL CORTEX
fascicolo: 3, volume: 10, anno: 2000,
pagine: 326 - 333
SICI:
1047-3211(200003)10:3<326:OAMPCA>2.0.ZU;2-L
Fonte:
ISI
Lingua:
ENG
Soggetto:
PRIMATE ORBITOFRONTAL CORTEX; PROGRESSIVE RATIO SCHEDULE; IBOTENIC ACID LESIONS; BEHAVIORAL SENSITIZATION; 6-HYDROXYDOPAMINE LESIONS; CORTICAL PROJECTIONS; MEDIODORSAL NUCLEUS; VENTRAL STRIATUM; MACAQUE MONKEYS; COCAINE ABUSERS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
54
Recensione:
Indirizzi per estratti:
Indirizzo: Porrino, LJ Wake Forest Univ, Sch Med, Dept Physiol & Pharmacol, Ctr Neurobiol Invest Abused Drugs, Med Ctr Blvd, Winston Salem, NC 27157 USA Wake Forest Univ Med Ctr Blvd Winston Salem NC USA 27157 7 USA
Citazione:
L.J. Porrino e D. Lyons, "Orbital and medial prefrontal cortex and psychostimulant abuse: Studies inanimal models", CEREB CORT, 10(3), 2000, pp. 326-333

Abstract

One approach to pursuing questions about the neural substrates that support substance abuse-related behaviors involves the use of animal models. Carefully controlled animal experiments can be conducted without the confounds commonly found in studies of human addicts, such as polydrug abuse, variable drug history and premorbid psychiatric conditions. The present paper considers the orbitofrontal and related limbic prefrontal cortex in the contextof such models of substance abuse. first, the importance of recognizing the heterogeneous structural and functional nature of orbitofrontal cortex inboth rodents and primates is addressed, and the results of studies involving the prefrontal cortex in substance abuse-related behaviors are considered in light of this diversity. Second, data from metabolic mapping studies are described that indicate that the pattern of functional activity within medial and orbitofrontal cortex shifts as the duration of exposure to drugs such as cocaine is extended. These functional differences, in turn, may reflect progressive phases of the addictive process. In order to understand the neurobiological consequences of long-term drug use, it will be important to establish the differing roles played by distinct anatomical territories within orbital and medial prefrontal cortex during the course of chronic substance abuse.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/03/20 alle ore 08:20:54