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Titolo:
Complex-type chromosomal exchanges in blood lymphocytes during radiation therapy correlate with acute toxicity
Autore:
Yamada, S; Durante, M; Ando, K; Furusawa, Y; Kawata, T; Majima, H; Tsujii, H;
Indirizzi:
Natl Inst Radiol Sci, Inage Ku, Chiba 2638555, Japan Natl Inst Radiol SciChiba Japan 2638555 Inage Ku, Chiba 2638555, Japan
Titolo Testata:
CANCER LETTERS
fascicolo: 2, volume: 150, anno: 2000,
pagine: 215 - 221
SICI:
0304-3835(20000331)150:2<215:CCEIBL>2.0.ZU;2-0
Fonte:
ISI
Lingua:
ENG
Soggetto:
DOSE-RATE IRRADIATION; INTRINSIC RADIOSENSITIVITY; SKIN FIBROBLASTS; CANCER-PATIENTS; T-LYMPHOCYTES; DOSIMETRY; IMPACT;
Keywords:
radiotherapy; chromosomal aberrations; predictive assay; oesophageal cancer; morbidity; complex exchanges;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
17
Recensione:
Indirizzi per estratti:
Indirizzo: Yamada, S Natl Inst Radiol Sci, Inage Ku, 9-1-4 Anagawa, Chiba 2638555, Japan Natl Inst Radiol Sci 9-1-4 Anagawa Chiba Japan 2638555 5, Japan
Citazione:
S. Yamada et al., "Complex-type chromosomal exchanges in blood lymphocytes during radiation therapy correlate with acute toxicity", CANCER LETT, 150(2), 2000, pp. 215-221

Abstract

The new method of chemical-induced premature chromosome condensation combined with fluorescence in situ hybridization was used to analyze chromosomaldamage in peripheral blood mononuclear lymphocytes of patients undergoing radiation treatment for esophageal cancer with high-energy X-rays or accelerated carbon ions at the National Institute of Radiological Sciences (Chiba, Japan). Total number of aberrant cells correlated with radiation held size, but no correlation was found with acute toxicity. A high frequency of complex-type exchanges were also recorded. This aberration type presented a high individual variability, and correlated well with the acute morbidity. Cytogenetic analysis by interphase chromosome painting is proposed as a useful tool for monitoring normal tissue effects during radiotherapy. (C) 2000 Elsevier Science Ireland Ltd, All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 10/07/20 alle ore 03:13:20