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Titolo:
Detection of human papillomavirus DNA in bronchopulmonary carcinomas by Hybrid Capture II - A study of 185 tumors
Autore:
Clavel, CE; Nawrocki, B; Bosseaux, B; Poitevin, G; Putaud, IC; Mangenojean, CC; Monteau, M; Birembaut, PL;
Indirizzi:
INSERM, U514, Lab Pol Bouin, F-51100 Reims, France INSERM Reims France F-51100 , U514, Lab Pol Bouin, F-51100 Reims, France Polyclin Courlancy, Reims, France Polyclin Courlancy Reims FrancePolyclin Courlancy, Reims, France
Titolo Testata:
CANCER
fascicolo: 6, volume: 88, anno: 2000,
pagine: 1347 - 1352
SICI:
0008-543X(20000315)88:6<1347:DOHPDI>2.0.ZU;2-7
Fonte:
ISI
Lingua:
ENG
Soggetto:
SQUAMOUS-CELL CARCINOMAS; POLYMERASE CHAIN-REACTION; BRONCHIAL EPITHELIAL-CELLS; P53 PROTEIN ACCUMULATION; LUNG-CARCINOMA; MALIGNANT-TUMORS; CANCER; HYBRIDIZATION; MUTATIONS; INFECTION;
Keywords:
human papillomavirus; lung carcinoma; Hybrid Capture II; phase liquid hybridization; squamous cell carcinoma; adenocarcinoma;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
43
Recensione:
Indirizzi per estratti:
Indirizzo: Clavel, CE INSERM, U514, Lab Pol Bouin, 45 Rue Cognacq Jay, F-51100 Reims,France INSERM 45 Rue Cognacq Jay Reims France F-51100 0 Reims, France
Citazione:
C.E. Clavel et al., "Detection of human papillomavirus DNA in bronchopulmonary carcinomas by Hybrid Capture II - A study of 185 tumors", CANCER, 88(6), 2000, pp. 1347-1352

Abstract

BACKGROUND. Some human papillomaviruses (HPVs) are oncogenic in the cervixand are also associated with benign and malignant proliferations in other organs. Currently, the association of HPV with tumors of the lower respiratory tract is not so clearly defined because the studies are difficult to compare; series of cases reported from different geographic regions have usedfrozen or formalin fixed samples and a variety of techniques of HPV detection. METHODS. The authors studied the prevalence of HPV in a large series of 185 frozen bronchopulmonary tumor samples with a new solution hybridization technique, Hybrid Capture II assay. This test is largely applied in cervicalpathology. Its sensitivity is very close to the sensitivity of PCR. It allows the detection of 18 mucosal HPV types, divided into 1 oncogenic and 1 nononcogenic group. RESULTS. Oncogenic HPV DNA was detected by the Hybrid Capture II assay in 5 cases (2.7%) of 185 (3 males and 2 females). In the rare positive cases detected, the authors could not find any consistent morphologic changes classically associated with HPV infection in anogenital lesions, such as koilocytosis. CONCLUSIONS. Oncogenic HPV DNA is detected in a small proportion of cases of bronchopulmonary carcinoma, and thus HPV infection appears to play a limited role in the tumorigenesis of most lung carcinomas. Cancer 2000;88:1347-52. (C) 2000 American Cancer Society.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/01/21 alle ore 15:37:56