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Titolo:
Cytogenetic abnormalities in the myelodysplastic syndromes and occupational or environmental exposure
Autore:
West, RR; Stafford, DA; White, AD; Bowen, DT; Padua, RA;
Indirizzi:
Univ Wales Coll Med, Cardiff CF4 4XN, S Glam, Wales Univ Wales Coll Med Cardiff S Glam Wales CF4 4XN f CF4 4XN, S Glam, Wales
Titolo Testata:
BLOOD
fascicolo: 6, volume: 95, anno: 2000,
pagine: 2093 - 2097
SICI:
0006-4971(20000315)95:6<2093:CAITMS>2.0.ZU;2-1
Fonte:
ISI
Lingua:
ENG
Soggetto:
ACUTE NONLYMPHOCYTIC LEUKEMIA; CYTOTOXIC THERAPY; CLINICAL-PROGRESS; MYELOID-LEUKEMIA; RAS MUTATIONS; IN-VITRO; CANCER; APOPTOSIS; KARYOTYPE; LYMPHOMA;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
38
Recensione:
Indirizzi per estratti:
Indirizzo: West, RR Univ Wales Coll Med, Heath Pk, Cardiff CF4 4XN, S Glam, Wales Univ Wales Coll Med Heath Pk Cardiff S Glam Wales CF4 4XN , Wales
Citazione:
R.R. West et al., "Cytogenetic abnormalities in the myelodysplastic syndromes and occupational or environmental exposure", BLOOD, 95(6), 2000, pp. 2093-2097

Abstract

Patients with myelodysplastic syndromes (MDS) have high frequencies of cytogenetic abnormalities and evidence is accumulating of associations betweenexposure history and primary MDS, The objective of this article is to examine the relationship between histories of occupational or environmental exposure and presence of cytogenetic abnormalities. A case control study of MDS patients estimated lifetime exposure to more than 90 potential hazards in400 age, sex, and area of residence matched patient and control pairs. A parallel cytogenetics study undertaken at time of diagnosis, independently of any knowledge of exposure history, identified 75 cytogenetically abnormaland 139 normal (186 not studied). Odds ratios of MDS patients and their matched controls were compared for 3 groups: cytogenetically abnormal, normal, and not known. The odds ratios for all exposures combined were possibly higher among cytogenetically abnormal 2.0 (95% confidence interval 0.8-5.9) than among normal 1.0 (0.6-1.8). This pattern was observed for exposure to semimetals, abnormal 4.0 (0.4-195.1) and normal 0.5 (0.1-1.0) and inorganicdusts, 1.6 (0.6-3.8) and 0.4 (0.1-1.4) respectively. The pattern was principally in abnormalities in chromosomes 5 and 7. For organic chemicals and radiation, the odds ratios for both cytogenetically abnormal and normal weremarginally raised: organic 1.8 (0.6-6.0) and 1.3 (0.6-2.9), respectively, and radiation 1.7 (0.5-5.6) and 1.3 (0.4-4.7) respectively. For radiation, abnormalities were mostly in chromosome 8. This study of association between exposures and cytogenetics in primary MDS complements those previously reported in secondary MDS and may provide some insight into pathogenetic mechanisms that lead to development of MDS. (C) 2000 by The American Society ofHematology.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 09/08/20 alle ore 23:04:01