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Titolo:
N-{[1-(2-phenylethyl)pyrrolidin-2-yl]methyl}cyclohexane-carboxamides as selective 5-HT1A receptor agonists
Autore:
Fujio, M; Togo, Y; Tomozane, H; Kuroita, T; Morio, Y; Katayama, J; Matsumoto, Y;
Indirizzi:
Yoshitomi Pharmaceut Ind Ltd, Div Pharmaceut Res, Drug Discovery Labs, Exploratory Res 1, Iruma, Saitama 3580026, Japan Yoshitomi Pharmaceut Ind LtdIruma Saitama Japan 3580026 a 3580026, Japan Yoshitomi Pharmaceut Ind Ltd, Div Pharmaceut Res, Chuo Ku, Osaka 5410042, Japan Yoshitomi Pharmaceut Ind Ltd Osaka Japan 5410042 u, Osaka 5410042, Japan Yoshitomi Pharmaceut Ind Ltd, Div Pharmaceut Res, Drug Discovery Labs, Exploratory Res 2, Hirakata, Osaka 5731153, Japan Yoshitomi Pharmaceut Ind Ltd Hirakata Osaka Japan 5731153 5731153, Japan
Titolo Testata:
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
fascicolo: 5, volume: 10, anno: 2000,
pagine: 509 - 512
SICI:
0960-894X(20000306)10:5<509:NAS>2.0.ZU;2-U
Fonte:
ISI
Lingua:
ENG
Soggetto:
DOPAMINE RECEPTOR; METOCLOPRAMIDE; ANTAGONIST; AFFINITIES; SULPIRIDE; AGENTS; RAT; D-2;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
16
Recensione:
Indirizzi per estratti:
Indirizzo: Fujio, M Yoshitomi Pharmaceut Ind Ltd, Div Pharmaceut Res, Drug Discovery Labs, Exploratory Res 1, 7-25 Koyata 3 Chome, Iruma, Saitama 3580026, JapanYoshitomi Pharmaceut Ind Ltd 7-25 Koyata 3 Chome Iruma Saitama Japan 3580026
Citazione:
M. Fujio et al., "N-{[1-(2-phenylethyl)pyrrolidin-2-yl]methyl}cyclohexane-carboxamides as selective 5-HT1A receptor agonists", BIOORG MED, 10(5), 2000, pp. 509-512

Abstract

A series of benzamides was synthesized as selective agonists for the 5-HT1A receptor. It was found that (S)-N-{[1-(2-phenylethyl)pyrrolidin-2-yl]methyl}cyclohexanecarboxamide(7-(S)) has potent and selective agonistic activity for the 5-HT1A receptor (5-HT1A; K-i = 0.49 nmol/L, D-2; IC50 = >1000 nmol/L, 5-HT2; K-i = 240 nmol/L). (C) 2000 Elsevier Science Ltd. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 28/03/20 alle ore 23:41:49