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Titolo:
Low baseline and yohimbine-stimulated plasma neuropeptide Y (NPY) levels in combat-related PTSD
Autore:
Rasmusson, AM; Hauger, RL; Morgan, CA; Bremner, JD; Charney, DS; Southwick, SM;
Indirizzi:
VA Connecticut Healthcare Syst, Psychiat Serv 116A, W Haven, CT 06516 USA VA Connecticut Healthcare Syst W Haven CT USA 06516 W Haven, CT 06516 USA Natl Ctr PTSD, W Haven, CT 06516 USA Natl Ctr PTSD W Haven CT USA 06516Natl Ctr PTSD, W Haven, CT 06516 USA Yale Univ, Sch Med, Dept Psychiat, New Haven, CT USA Yale Univ New Haven CT USA iv, Sch Med, Dept Psychiat, New Haven, CT USA Univ Calif San Diego, San Diego VA Healthcare Syst, San Diego, CA 92103 USA Univ Calif San Diego San Diego CA USA 92103 Syst, San Diego, CA 92103 USA Univ Calif San Diego, Dept Psychiat, San Diego, CA 92103 USA Univ Calif San Diego San Diego CA USA 92103 hiat, San Diego, CA 92103 USA
Titolo Testata:
BIOLOGICAL PSYCHIATRY
fascicolo: 6, volume: 47, anno: 2000,
pagine: 526 - 539
SICI:
0006-3223(20000315)47:6<526:LBAYPN>2.0.ZU;2-V
Fonte:
ISI
Lingua:
ENG
Soggetto:
POSTTRAUMATIC-STRESS-DISORDER; CORTICOTROPIN-RELEASING FACTOR; URINARY CATECHOLAMINE EXCRETION; RECEPTOR ANTAGONIST BIBP3226; ANXIOLYTIC-LIKE ACTION; RAT-BRAIN REGIONS; VIETNAM VETERANS; CEREBROSPINAL-FLUID; PSYCHOPHYSIOLOGICAL ASSESSMENT; PHYSIOLOGICAL-RESPONSES;
Keywords:
posttraumatic stress disorder; PTSD; neuropeptide Y; combat stress; anxiety; cardiovascular;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
108
Recensione:
Indirizzi per estratti:
Indirizzo: Rasmusson, AM VA Connecticut Healthcare Syst, Psychiat Serv 116A, 950 Campbell Ave, W Haven, CT 06516 USA VA Connecticut Healthcare Syst 950 CampbellAve W Haven CT USA 06516
Citazione:
A.M. Rasmusson et al., "Low baseline and yohimbine-stimulated plasma neuropeptide Y (NPY) levels in combat-related PTSD", BIOL PSYCHI, 47(6), 2000, pp. 526-539

Abstract

Background: Consistent with many studies demonstrating enhanced reactivityof the sympathetic nervous system in posttraumatic stress disorder (PTSD) the administration of yohimbine, a noradrenergic alpha(2)-antagonist, has been shown to increase core symptoms of PTSD and to induce greater increasesin plasma 3-methyl-4-hydroxy-phenyl-glycol (MHPG) in subjects with PTSD compared with healthy control subjects. In turn, neuropeptide Y (NPY) has been shown to inhibit the release of norepinephrine from sympathetic noradrenergic neurons. Methods: In the following study, plasma NPY responses to yohimbine and placebo were measured in a subgroup of 18 subjects with PTSD and 8 healthy control subjects who participated in the previous study of the effect of yohimbine on plasma MHPG. Results: The PTSD subjects had lower baseline plasma NPY and blunted yohimbine-stimulated increases in plasma NPY compared with the healthy control subjects. Within the PTSD group, baseline plasma NPY levels correlated negatively with combat exposure scale scores, baseline PTSD and panic symptoms, and yohimbine-stimulated increases in MHPG and systolic blood pressure. Conclusions: This study suggests that combat stress-induced decreases in plasma NPY may mediate, in part, the noradrenergic system hyperreactivity observed in combat-related PTSD. The persistence of this decrease in plasma NPY may contribute to symptoms of hyperarousal and the expression of exaggerated alarm reactions anxiety reactions, or both in combat veterans with PTSD long after war. (C) 2000 Society of Biological Psychiatry.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 19/01/20 alle ore 09:22:04