Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
[I-123]-beta-CIT SPECT imaging shows reduced brain serotonin transporter availability in drug-free depressed patients with seasonal affective disorder
Autore:
Willeit, M; Praschak-Rieder, N; Neumeister, A; Pirker, W; Asenbaum, S; Vitouch, O; Tauscher, J; Hilger, E; Stastny, J; Brucke, T; Kasper, S;
Indirizzi:
Univ Vienna, Dept Gen Psychiat, Vienna, Austria Univ Vienna Vienna Austria v Vienna, Dept Gen Psychiat, Vienna, Austria Univ Vienna, Dept Neurol, Vienna, Austria Univ Vienna Vienna AustriaUniv Vienna, Dept Neurol, Vienna, Austria Univ Vienna, Dept Nucl Med, Vienna, Austria Univ Vienna Vienna AustriaUniv Vienna, Dept Nucl Med, Vienna, Austria Univ Vienna, Inst Psychol, Vienna, Austria Univ Vienna Vienna AustriaUniv Vienna, Inst Psychol, Vienna, Austria
Titolo Testata:
BIOLOGICAL PSYCHIATRY
fascicolo: 6, volume: 47, anno: 2000,
pagine: 482 - 489
SICI:
0006-3223(20000315)47:6<482:[SISRB>2.0.ZU;2-W
Fonte:
ISI
Lingua:
ENG
Soggetto:
I-123 BETA-CIT; H-3 PAROXETINE BINDING; LIGHT THERAPY; MESSENGER-RNA; UPTAKE SITES; IN-VIVO; DOPAMINE; AFFINITY; 2-BETA-CARBOMETHOXY-3-BETA-(4-IODOPHENYL)TROPANE; CHLOROPHENYLPIPERAZINE;
Keywords:
beta-CIT; SPECT; serotonin; serotonin transporter; depression; seasonal affective disorder;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
47
Recensione:
Indirizzi per estratti:
Indirizzo: Willeit, M Univ Vienna, Dept Gen Psychiat, Waehringer Gurtel 18-20, Vienna, Austria Univ Vienna Waehringer Gurtel 18-20 Vienna Austria a, Austria
Citazione:
M. Willeit et al., "[I-123]-beta-CIT SPECT imaging shows reduced brain serotonin transporter availability in drug-free depressed patients with seasonal affective disorder", BIOL PSYCHI, 47(6), 2000, pp. 482-489

Abstract

Background: Numerous findings indicate alterations in brain serotonin systems in seasonal affective disorder (SAD). [I-123]-2-beta-carbomethoxy-3-beta-(4-iodophenyl)-tropane ([I-123]-beta-CIT) labels serotonin transporters (5-HTTs) in the midbrain. We performed a [I-123]-beta-CIT single photon emission computer tomography (SPECT) study under the hypothesis of lower [I-123]-beta-CIT binding reflecting reduced central 5-HTT availability in depressed SAD patients. Methods: Depressed SAD patients and healthy control subjects were investigated using [I-123]-beta-CIT SPECT 4 hours and again 24 hours after tracer injection. Subjects had either never used psychotropic medication or had been drug-free for at least 6 months prior to the investigation. Specific-to-nondisplaceable partition coefficient (V-3") was calculated for the thalamus-hypothalamus and the midbrain-pons; the cerebellum sewed as a reference region. Results: Patients showed a reduction in V-3" in thalamus-hypothalamus (2.41 +/- 0.3 vs. 2.84 +/- 0.4; p = .026) 24 hours post tracer injection (p.i). No difference between patients and control subjects was found in midbrain-pens (1.31 +/- 0.2 vs. 1.42 +/- 0.2; p = .39). No differences were detectedin the SPECT acquisitions 4 hours p.i. Conclusions: Depressed SAD patients showed lower specific-to-nondisplaceable [I-123]-beta-CIT binding in the region of interest (ROI) thalamus-hypothalamus. The small size of the midbrain-pens ROI may have contributed to thefailure to show a difference in this ROI as well. Similar to reduced midbrain 5-HTT availability in nonseasonal depression, depression in SAD seems to be associated with reduced 5-HTT availability to the thalamus-hypothalamus. (C) 2000 Society of Biological Psychiatry.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 17/09/19 alle ore 22:42:42