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Titolo:
The aetiology of Type I diabetes
Autore:
Chowdhury, TA; Mijovic, CH; Barnett, AH;
Indirizzi:
Birmingham Heartlands Hosp, Dept Med, Ctr Diabet, Birmingham B9 5SS, W Midlands, England Birmingham Heartlands Hosp Birmingham W Midlands England B95SS , England Queen Elizabeth Hosp, Dept Med, Birmingham B15 2TT, W Midlands, England Queen Elizabeth Hosp Birmingham W Midlands England B15 2TT lands, England Birmingham Heartlands Hosp, Undergrad Ctr, Birmingham B9 5SS, W Midlands, England Birmingham Heartlands Hosp Birmingham W Midlands England B9 5SS , England
Titolo Testata:
BEST PRACTICE & RESEARCH CLINICAL ENDOCRINOLOGY & METABOLISM
fascicolo: 2, volume: 13, anno: 1999,
pagine: 181 - 195
SICI:
1521-690X(199907)13:2<181:TAOTID>2.0.ZU;2-8
Fonte:
ISI
Lingua:
ENG
Soggetto:
INSULIN GENE; HLA-DQ; SUSCEPTIBILITY GENES; TRANSCRIPTION LEVELS; IMMUNE-RESPONSES; CANDIDATE GENES; MELLITUS IDDM; RISK FACTOR; NOD MOUSE; ASSOCIATION;
Keywords:
Type I diabetes; susceptibility genes; major histocompatibility complex (MHC); human leukocyte antigen (HLA); environmental factors; viruses; cows' milk protein;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
87
Recensione:
Indirizzi per estratti:
Indirizzo: Chowdhury, TA Birmingham Heartlands Hosp, Dept Med, Ctr Diabet, Bordesley Green E, Birmingham B9 5SS, W Midlands, England Birmingham Heartlands Hosp Bordesley Green E Birmingham W Midlands England B9 5SS
Citazione:
T.A. Chowdhury et al., "The aetiology of Type I diabetes", BEST PRAC R, 13(2), 1999, pp. 181-195

Abstract

The aetiology of Type 1 diabetes involves both genetic and environmental factors. The genes implicated are 'susceptibility genes', which modify risk. Individual susceptibility genes may not be required and are not sufficientfor disease development. The strongest genetic risk component is encoded within the major histocompatibility complex (MHC) and is designated IDDM1. The HLA-DQ genes contribute to the risk, but so may other MHC-encoded genes. The susceptibility encoded by IDDM2 refers to a variable number of tandem repeats in the insulin gene region. Many other genomic regions have been designated as susceptibility intervals potentially containing candidate genes. Environmental factors appear to be important in disease expression in either a causative or a protective role. Epidemiological data indicate that such factors operate from early in life. Viral infection(s) may have a disease-initiating and/ or accelerating effect. A potential diabetogenic role forcows' milk protein remains unconfirmed. Further research is necessary to elucidate fully the aetiological factors involved and how they interact.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 02/07/20 alle ore 18:36:35