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Titolo:
Prevalence of beta-cell and thyroid autoantibody positivity in schoolchildren during three-year follow-up
Autore:
Lindberg, B; Carlsson, A; Ericsson, UB; Kockum, I; Lernmark, A; Landin-Olsson, M; Sundkvist, G; Ivarsson, SA;
Indirizzi:
Univ Lund, Malmo Univ Hosp, Dept Pediat, S-20502 Malmo, Sweden Univ Lund Malmo Sweden S-20502 Hosp, Dept Pediat, S-20502 Malmo, Sweden
Titolo Testata:
AUTOIMMUNITY
fascicolo: 3, volume: 31, anno: 1999,
pagine: 175 - 185
SICI:
0891-6934(1999)31:3<175:POBATA>2.0.ZU;2-L
Fonte:
ISI
Lingua:
ENG
Soggetto:
DEPENDENT DIABETES-MELLITUS; GLUTAMIC-ACID DECARBOXYLASE; COMPETITIVE INSULIN AUTOANTIBODIES; MATCHED CONTROL CHILDREN; ISLET-CELL; FRENCH SCHOOLCHILDREN; UNAFFECTED RELATIVES; SWEDISH CHILDREN; ANTIBODIES; HLA;
Keywords:
autoantibodies; autoimmunity; thyroiditis; type 1 diabetes mellitus;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
61
Recensione:
Indirizzi per estratti:
Indirizzo: Lindberg, B Univ Lund, Malmo Univ Hosp, Dept Pediat, S-20502 Malmo, SwedenUniv Lund Malmo Sweden S-20502 Pediat, S-20502 Malmo, Sweden
Citazione:
B. Lindberg et al., "Prevalence of beta-cell and thyroid autoantibody positivity in schoolchildren during three-year follow-up", AUTOIMMUN, 31(3), 1999, pp. 175-185

Abstract

The prevalence of autoantibodies against the 65 kD isoform of glutamic acid decarboxylase (GAD65Ab), insulin (IAA), islet cells (ICA), thyroid peroxidase (TPOAb) and thyroglobulin (TgAb), in relation to HLA-DR types, was assessed in 310 (HLA in 280) twelve-year-old children during three-year follow-up, Altogether, 26.8% (83/310) of the children were found to carry at least one autoantibody, The HLA-DR3/DR4 genotype was significantly more prevalent in the subgroup of children GAD65AB-positive on at least one occasion than among GAD65Ab-negative children [33% (2/6) vs. 5% (12/274); p = 0.03], as was the HLA-DR4/x genotype among children seropositive for at least one thyroid autoantibody, compared to the corresponding seronegative subgroup [52% (34/65) vs. 34% (74/215); p=0.01]. The proportion of children seropositive in at least one of the three tests was 1.9% (6/310) for GAD65Ab, 2.6% (8/310) for IAA, 5.2% (16/310) for ICA, 11.3% (35/310) for TPOAb and 19.4% (60/310) for TgAb- All autoantibodies except GAD65Ab tended to disappear during follow-up, and at the three-year follow-up IAA had disappeared in 50% (2/4) of cases, ICA in 67% (6/9), TPOAb in 30% (6/20) and TgAb in 38% (18/47)of cases, The turnover of seropositive subjects and the large proportion of children seropositive for at least one islet or thyroid autoantibody during a three-year follow-up suggest transient autoantibodies to be more common than is discernible in cross-sectional investigations.

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Documento generato il 01/12/20 alle ore 00:32:17