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Titolo:
Diabetes mellitus - Subclinical cardiovascular disease and risk of incident cardiovascular disease and all-cause mortality
Autore:
Kuller, LH; Velentgas, P; Barzilay, J; Beauchamp, NJ; OLeary, DH; Savage, PJ;
Indirizzi:
Univ Pittsburgh, Grad Sch Publ Hlth, Dept Epidemiol, Pittsburgh, PA 15261 USA Univ Pittsburgh Pittsburgh PA USA 15261 idemiol, Pittsburgh, PA 15261 USA CHS Coordinating Ctr, Seattle, WA USA CHS Coordinating Ctr Seattle WA USA HS Coordinating Ctr, Seattle, WA USA Kaiser Permanente Georgia, Tucker, GA USA Kaiser Permanente Georgia Tucker GA USA rmanente Georgia, Tucker, GA USA Johns Hopkins Radiol, Neuroradiol Div, Baltimore, MD USA Johns Hopkins Radiol Baltimore MD USA Neuroradiol Div, Baltimore, MD USA NHLBI, Div Epidemiol & Clin Applicat, Bethesda, MD 20892 USA NHLBI Bethesda MD USA 20892 emiol & Clin Applicat, Bethesda, MD 20892 USA Tufts New England Med Ctr, Dept Radiol, Boston, MA USA Tufts New England Med Ctr Boston MA USA Ctr, Dept Radiol, Boston, MA USA
Titolo Testata:
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
fascicolo: 3, volume: 20, anno: 2000,
pagine: 823 - 829
SICI:
1079-5642(200003)20:3<823:DM-SCD>2.0.ZU;2-4
Fonte:
ISI
Lingua:
ENG
Soggetto:
CORONARY HEART-DISEASE; AVERAGE CHOLESTEROL LEVELS; MYOCARDIAL-INFARCTION; OLDER ADULTS; HEALTH; ATHEROSCLEROSIS; PREVALENCE; GLUCOSE; EVENTS; PRAVASTATIN;
Keywords:
diabetes; atherosclerosis; subclinical disease; stroke; heart attack;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
43
Recensione:
Indirizzi per estratti:
Indirizzo: Kuller, LH Univ Pittsburgh, Grad Sch Publ Hlth, Dept Epidemiol, Room A527,130 DeSoto St, Pittsburgh, PA 15261 USA Univ Pittsburgh Room A527,130 DeSoto St Pittsburgh PA USA 15261
Citazione:
L.H. Kuller et al., "Diabetes mellitus - Subclinical cardiovascular disease and risk of incident cardiovascular disease and all-cause mortality", ART THROM V, 20(3), 2000, pp. 823-829

Abstract

Previously diagnosed diabetes mellitus, newly diagnosed diabetes mellitus,and impaired glucose tolerance are important determinants of the risk of clinical cardiovascular disease (CVD). We have evaluated the relation of patients with subclinical CVD, diabetes, and impaired glucose tolerance and "normal" subjects and the risk of clinical CVD in the Cardiovascular Health Study. Diabetes (1343), impaired glucose tolerance (1433), and normal (2421)were defined by World Health Organization criteria at baseline in 1989 to 1990. The average follow-up was 6.4 years (mean age 73 years). Diabetics had a higher prevalence of clinical and subclinical CVD at baseline. Comparedwith diabetes in the absence of subclinical disease, the presence of subclinical CVD and diabetes was associated with significant increased adjusted relative risk of death (1.5, CI 0.93 to 2.41), relative risk of incident coronary heart disease (1.99, CI 1.25 to 3.19), and incident myocardial infarction (1.93, CI 0.96 to 3.91). The risk of clinical events was greater for participants with a history of diabetes compared with newly diagnosed diabetics at baseline. Compared with nondiabetic nonhypertensive subjects without subclinical disease, patients with a combination of diabetes, hypertension, and subclinical disease had a 12-fold increased risk of stroke. Fasting blood glucose levels were a weak predictor of incident coronary heart disease as were most other risk factors. Subclinical CVD was the primary determinant of clinical CVD among diabetics in the Cardiovascular Health Study.

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Documento generato il 30/11/20 alle ore 10:11:17