Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Cholesterol-lowering treatment is associated with improvement in coronary vascular remodeling and endothelial function in patients with normal or mildly diseased coronary arteries
Autore:
Hamasaki, S; Higano, ST; Al Suwaidi, J; Nishimura, RA; Miyauchi, K; Holmes, DR; Lerman, A;
Indirizzi:
Mayo Clin & Mayo Fdn, Ctr Coronary Physiol & Imaging, Div Cardiovasc Dis, Rochester, MN 55905 USA Mayo Clin & Mayo Fdn Rochester MN USA 55905 Dis, Rochester, MN 55905 USA Mayo Clin & Mayo Fdn, Dept Internal Med, Rochester, MN 55905 USA Mayo Clin& Mayo Fdn Rochester MN USA 55905 Med, Rochester, MN 55905 USA
Titolo Testata:
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
fascicolo: 3, volume: 20, anno: 2000,
pagine: 737 - 743
SICI:
1079-5642(200003)20:3<737:CTIAWI>2.0.ZU;2-F
Fonte:
ISI
Lingua:
ENG
Soggetto:
INTRAVASCULAR ULTRASOUND; COMPENSATORY ENLARGEMENT; HEART-DISEASE; SERUM-CHOLESTEROL; BLOOD-FLOW; EXPERIMENTAL HYPERCHOLESTEROLEMIA; INTRACORONARY ULTRASOUND; LIPOPROTEIN CHOLESTEROL; DEPENDENT RELAXATION; CLINICAL EVENTS;
Keywords:
remodeling; hypercholesterolemia; cholesterol; endothelium; ultrasonics;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
56
Recensione:
Indirizzi per estratti:
Indirizzo: Lerman, A Mayo Clin & Mayo Fdn, Ctr Coronary Physiol & Imaging, Div Cardiovasc Dis, 200 1st St SW, Rochester, MN 55905 USA Mayo Clin & Mayo Fdn 200 1st St SW Rochester MN USA 55905 05 USA
Citazione:
S. Hamasaki et al., "Cholesterol-lowering treatment is associated with improvement in coronary vascular remodeling and endothelial function in patients with normal or mildly diseased coronary arteries", ART THROM V, 20(3), 2000, pp. 737-743

Abstract

Coronary vascular remodeling and altered endothelial function have been described in the early stages of native atherosclerosis. The purpose of this study was to evaluate the association between cholesterol-lowering therapy and coronary vascular remodeling and endothelial function in patients with normal or mildly diseases coronary arteries. Patients (N=101) with normal or mildly diseased coronary arteries by coronary angiography underwent intravascular ultrasound examination of the left anterior descending coronary artery. Vessel and lumen area, atherosclerotic plaque area, and plaque morphology were evaluated. Vascular reactivity was examined with the use of intracoronary adenosine, acetylcholine, and nitroglycerin. Patients were dividedinto 3 groups based on the total cholesterol levels: group 1 (n=25), patients with a history of hypercholesterolemia adequately treated (total cholesterol <240 mg/dL); group 2 (n=26), patients with hypercholesterolemia not adequately controlled (total cholesterol greater than or equal to 240 mg/dL); and group 3 (n=50), patients without hypercholesterolemia. Vessel area and lumen area were significantly greater in groups 1 and 3 than in group 2 (for respective values in groups 1, 2, and 3: vessel area 11.9+/-0.5, 10.6+/-0.4, and 11.8+/-0.4 mm(2), both P<0.05; lumen area 8.3+/-0.4, 6.9+/-0.3. and 8.9+/-0.3 mm(2), both P<0.01). However, plaque areas in groups 1 and 2 were similar. Furthermore, acetylcholine-induced percent increases in coronary blood flow were significantly greater in groups 1 and 3 than in group 2 (for respective values in groups 1, 2, and 3: 70.5+/-20.1%, 22.8+/-13.7%, and 68.6+/-14.8%, both P<0.05). Cholesterol-lowering treatment is associatedwith an improvement in coronary lumen area that results not from a decrease in plaque area but from an increase in vessel area, reflecting vascular remodeling. Additionally, this adaptive process may occur in association with an improvement of endothelium-dependent vasodilation of the resistance coronary artery.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 07/07/20 alle ore 06:25:55