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Titolo:
Altered flow-induced arterial remodeling in vimentin-deficient mice
Autore:
Schiffers, PMH; Henrion, D; Boulanger, CM; Colucci-Guyon, E; Langa-Vuves, F; van Essen, H; Fazzi, GE; Levy, BI; De Mey, JGR;
Indirizzi:
Univ Limburg, Dept Pharmacol & Toxicol, NL-6200 MD Maastricht, NetherlandsUniv Limburg Maastricht Netherlands NL-6200 MD D Maastricht, Netherlands Univ Limburg, Cardiovasc Res Inst Maastricht, NL-6200 MD Maastricht, Netherlands Univ Limburg Maastricht Netherlands NL-6200 MD D Maastricht, Netherlands Univ Paris 07, INSERM U141, IFR, Circulat Labs, Paris, France Univ Paris 07 Paris France SERM U141, IFR, Circulat Labs, Paris, France Inst Pasteur, Unite Biol Dev, Paris, France Inst Pasteur Paris FranceInst Pasteur, Unite Biol Dev, Paris, France
Titolo Testata:
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
fascicolo: 3, volume: 20, anno: 2000,
pagine: 611 - 616
SICI:
1079-5642(200003)20:3<611:AFARIV>2.0.ZU;2-4
Fonte:
ISI
Lingua:
ENG
Soggetto:
VASCULAR SMOOTH-MUSCLE; REDUCED BLOOD-FLOW; LACKING VIMENTIN; CAROTID-ARTERY; NITRIC-OXIDE; HYPERTENSIVE RATS; ENDOTHELIAL-CELLS; GROWTH; MECHANOTRANSDUCTION; CYTOSKELETON;
Keywords:
vimentin; arterial remodeling; blood flow; mice; carotid arteries;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
43
Recensione:
Indirizzi per estratti:
Indirizzo: De Mey, JGR Univ Limburg, Dept Pharmacol & Toxicol, POB 616, NL-6200 MD Maastricht, Netherlands Univ Limburg POB 616 Maastricht Netherlands NL-6200 MD rlands
Citazione:
P.M.H. Schiffers et al., "Altered flow-induced arterial remodeling in vimentin-deficient mice", ART THROM V, 20(3), 2000, pp. 611-616

Abstract

The endothelial cytoskeleton plays a key role in arterial responses to acute changes in shear stress. We evaluated whether the intermediate filament protein vimentin is involved in the structural responses of arteries to chronic changes in blood flow (BF). In wild-type mice (V+/+) and in vimentin-deficient mice (V-/-), the left common carotid artery (LCA) was ligated nearits bifurcation, and 4 weeks later, the structures of the occluded and of the contralateral arteries were evaluated and compared with the structures of arteries from sham-operated mice. Body weight and mean carotid artery BFdid not differ between the strains, but LCA and right carotid artery (RCA)diameter (737 +/- 14 mu m [LCA] and 723 +/- 14 mu m [RCA] for V-/- versus 808 +/- 20 mu m [LCA] and 796 +/- 20 E-Lm [RCA] for V+/+) and medial cross-sectional area (CSAm) were significantly smaller in V-/- (21 +/- 1 and 22 +/- 2 X 10(3) mu m(2) for LCA and RCA, respectively) than in V+/+ (28 +/- 2 and 28 +/- 3 X 10(3) mu m(2) for LCA and RCA, respectively). In V+/+, LCA ligation eliminated BF in the occluded vessel (before ligation, 0.35 +/- 0.02 mL/min) and increased BF from 0.34 +/- 0.02 to 0.68 +/- 0.04 mL/min in the RCA. In V-/-, the BF change in the occluded LCA was comparable (from 0.38+/- 0.05 mL/min to zero-flow rates), but the BF increase in the RCA was less pronounced (from 0.33 +/- 0.02 to 0.50 +/- 0.05 mL/min). In the occludedLCA of V+/+, arterial diameter was markedly reduced (-162 mu m), and CSAm was significantly increased (5 X 10(3) mu m(2)), whereas in the high-flow RCA of V+/+, carotid artery diameter and CSAm were not significantly modified. In the occluded LCA of V-/-, arterial diameter was reduced to a lesser extent (-77 mu m) and CSAm was increased to a larger extent (10 X 10(3) mu m(2)) than in V+/+. In contrast to V+/+, the high-flow RCA of V-/- displayeda significant increase in diameter (52 mu m) and a significant increase inCSAm (5 X 10(3) mu m(2)). These observations provide the first direct evidence for a role of the cytoskeleton in flow-induced arterial remodeling, Furthermore, they dissociate (1) between acute and chronic arterial responsesto altered BF, (2) between alterations of lumen diameter and wall mass during arterial remodeling, and (3) between developmental and imposed flow-induced arterial remodeling.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/12/20 alle ore 16:14:45