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Titolo:
Effect of pentoxifylline on the healing of guinea pig tympanic membrane
Autore:
Lim, AAT; Washington, AP; Greinwald, JH; Lassen, LF; Holtel, MR;
Indirizzi:
USN, Med Ctr, Dept Otolaryngol Head & Neck Surg, Portsmouth, VA USA USN Portsmouth VA USA t Otolaryngol Head & Neck Surg, Portsmouth, VA USA USN, Med Ctr, Dept Pathol, Portsmouth, VA USA USN Portsmouth VA USAUSN, Med Ctr, Dept Pathol, Portsmouth, VA USA Tripler Army Med Ctr, Dept Otolaryngol Head & Neck Surg, Honolulu, HI 96859 USA Tripler Army Med Ctr Honolulu HI USA 96859 k Surg, Honolulu, HI 96859 USA
Titolo Testata:
ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY
fascicolo: 3, volume: 109, anno: 2000,
pagine: 262 - 266
SICI:
0003-4894(200003)109:3<262:EOPOTH>2.0.ZU;2-4
Fonte:
ISI
Lingua:
ENG
Soggetto:
EPIDERMAL GROWTH-FACTOR; SKIN-FLAP SURVIVAL; OCCLUSIVE DISEASE; PERFORATIONS; REPAIR;
Keywords:
guinea pig; pentoxifylline; tympanic membrane perforation;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
33
Recensione:
Indirizzi per estratti:
Indirizzo: Lim, AAT SGCQSL, Med Grp 375, Dept Otolaryngol Head & Neck Surg, 310 W Losey St, Scott AFB, IL 62225 USA SGCQSL 310 W Losey St Scott AFB IL USA 62225tt AFB, IL 62225 USA
Citazione:
A.A.T. Lim et al., "Effect of pentoxifylline on the healing of guinea pig tympanic membrane", ANN OTOL RH, 109(3), 2000, pp. 262-266

Abstract

Although most tympanic membrane perforations heal spontaneously, persistent perforations frequently require treatment by otolaryngologists. Initial management strategies include keeping the ear dry, ensuring aural hygiene, and using topical antibiotics. For persistent perforations. paper patching or myringoplasty may be required. Recently, agents such as hyaluronic acid and epidermal growth factor have been used to promote tympanic membrane healing. Similarly, pentoxifylline, a pharmaceutical agent with hemorrheological and antithrombotic properties, has been shown to increase perfusion and accelerate wound healing. This double-blinded prospective study attempts to examine the effect of pentoxifylline on tympanic membrane healing of 50 guinea pigs subjected to myringotomy. Serial examinations and histopathologic sectioning of the tympanic membranes revealed no significant difference in rate of healing or quality of repair between the pentoxifylline and controlgroups.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/07/20 alle ore 04:14:47