Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Hydrogen peroxide induces LFA-1-dependent neutrophil adherence to cardiac myocytes
Autore:
Lu, HF; Youker, K; Ballantyne, C; Entman, M; Smith, CW;
Indirizzi:
Baylor Coll Med, Dept Pediat, Sect Leukocyte Biol, Speros P Martel Lab Leukocyte Biol, Houston, TX 77030 USA Baylor Coll Med Houston TX USA 77030 eukocyte Biol, Houston, TX 77030 USA Baylor Coll Med, Dept Med, Methodist Hosp, Cardiovasc Sci Sect, Houston, TX 77030 USA Baylor Coll Med Houston TX USA 77030 vasc Sci Sect, Houston, TX 77030 USA Baylor Coll Med, Dept Med, Methodist Hosp, Cardiol Sect, Houston, TX 77030USA Baylor Coll Med Houston TX USA 77030 , Cardiol Sect, Houston, TX 77030USA Baylor Coll Med, Dept Microbiol & Immunol, Houston, TX 77030 USA Baylor Coll Med Houston TX USA 77030 iol & Immunol, Houston, TX 77030 USA
Titolo Testata:
AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY
fascicolo: 3, volume: 278, anno: 2000,
pagine: H835 - H842
SICI:
0363-6135(200003)278:3<H835:HPILNA>2.0.ZU;2-I
Fonte:
ISI
Lingua:
ENG
Soggetto:
INTERCELLULAR-ADHESION MOLECULE-1; PLATELET-ACTIVATING-FACTOR; OPEN-HEART-SURGERY; CD18-DEPENDENT MECHANISM; CARDIOPULMONARY BYPASS; MONOCLONAL-ANTIBODIES; CHEMOTACTIC FACTORS; REPERFUSION INJURY; CANINE MYOCARDIUM; ICAM-1;
Keywords:
reactive oxygen; inflammation;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
33
Recensione:
Indirizzi per estratti:
Indirizzo: Smith, CW Baylor Coll Med, Dept Pediat, Sect Leukocyte Biol, Speros P Martel Lab Leukocyte Biol, 1100 Bates Rm 6014, Houston, TX 77030 USA Baylor Coll Med 1100 Bates Rm 6014 Houston TX USA 77030 7030 USA
Citazione:
H.F. Lu et al., "Hydrogen peroxide induces LFA-1-dependent neutrophil adherence to cardiac myocytes", AM J P-HEAR, 278(3), 2000, pp. H835-H842

Abstract

Adult cardiac myocytes express intercellular adhesion molecule (ICAM)-1 inresponse to cytokine stimulation. This allows stable adhesion of chemotactically stimulated but not unstimulated neutrophils. In the current study, we demonstrated that brief exposure of ICAM-1-expressing cardiac myocytes toH2O2 promoted transient adhesive interactions between myocytes and neutrophils without added chemotactic factors. This transient adhesion differed intwo ways from the stable adhesion promoted by exogenous chemotactic factors. It occurred more rapidly, peaking within 15 min, and it was dependent onleukocyte function-associated antigen (LFA)-1 (CD11a/CD18) on the neutrophil interacting with ICAM-1 on the myocyte. In contrast, chemotactic factor-induced adhesion peaked at 60 min and was dependent on Mac-1 (CD11b/CD18). The transient adhesion could be completely inhibited by platelet-activatingfactor (PAF)-receptor antagonists WEB-2086 and SDZ-64-412. These results indicate that canine neutrophils may utilize both LFA-1 and Mac-1 to adhere to adult cardiac myocytes, with LFA-1 triggered by a PAF-like activity induced in myocytes by H2O2.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 18/01/21 alle ore 15:44:52